[The activity of antioxidant enzymes of erythrocytes under intensive physical activity on the background of D-ribose use].

Biochemical analysis of blood of 30 male rats with 240 +/- 20 g mass and 50 sportsmen at the age 17-20 years were done. They were subjected by intensive physical activity with D-ribose use and without it. Carbohydrate was being put into them before and after intensive physical activity during 5-7 days. The dose was 30-50 mg/kg of their body mass. Concentration of glucose, lactate and uric acids, level of malondialdehyde, activity of superoxide dismutase, glutathione peroxidase and glucose-6-phosphate dehydrogenase were defined in the male rats and sportsmen blood. It is shown that D-ribose use influences positive by to the dynamics of biochemical data in blood. It has taken place owing to the intensification of reutilization of purine mononucleotides and the activity of pentose cycle, as a result lipid peroxidation of membrane of erythrocytes reduces and state of antioxidation system improves.

[Use of plasmapheresis for correction of metabolic disorders in patients with surgical sepsis]. / Ispol'zovanie plazmafereza dlia korrektsii metabolicheskikh narushenii u bol'nykh s khirurgicheskom sepsisom.

Twenty-four patients aged 16-67 years with surgical sepsis developing as a result of pancreonecrosis, gynecological diseases, urological sepsis. closed abdominal injury, and suppurative inflammation of soft tissues were examined. Endotoxemia caused pronounced disorders in metabolism, particularly purine metabolism, and the associated lipid peroxidation processes. Plasmapheresis exerted a positive effect in patients with high concentration of medium molecular-weight polypeptides (more than 0.32 arb. units) in the blood, decreasing the mortality by 40.5%. At lower concentrations of these polypeptides in the blood (less than 0.32 arb. units) plasmapheresis is inefficient.

[Disorders of purine metabolism in patients with peritonitis complicated by sepsis]. / Narusheniia metabolizma purinov u bol'nykh peritonitom, oslozhnivshimsia sepsisom.

Progressive hypoxia and cell destruction leading to increased production of active oxygen forms by xanthinoxidase and manifesting by an increased level of uric acid in the blood in parallel with inhibited pentose cycle reaction due to low activity of glucose-6-phosphate dehydrogenase determine the severity of peritonitis.

[On the damaging mechanism of mixed wood dust]. / K mekhanizmu povrezhdaiushchego deistviia smeshannoi drevesnoi pyli.

The authors showed new immune and morphologic phenomenon--toxic lymphoinhibition--mixed wooden dust (wood laminate, plywood) induces decrease of circulating pool of lymphatic elements and increases mitotic activity in T-dependent zones of central and peripheral lymphatic organs. Pine dust used in experiments and having antigen effects of highly molecular substances activates macrophages and moderate functional stress of T-immunity. With this, leukocyte and lymphocyte counts grow, qualitative and quantitative parameters of phagocytosis increase as well.

[Carbohydrate metabolism upon disruption of monoaminergic regulatory mechanisms, developing in the early post-resuscitation period]. / Metabolizm uglevodov v usloviiakh narusheniia monoaminergicheskikh reguliatornykh mekhanizmov, razvivshegosiia v rannem postreanimatsionnom periode.

Within the early period after clinical death of various duration, hyperglycemia developed in dogs as a result of increased secretion of catecholamines; the rate of hyperglycemia depended on the severity of postresuscitation impairments of the central nervous system. Content of blood glucose was increased simultaneously with elevation of insulin production. Within 1-2 hrs after administration of dihydroxyphenylalanine the excessive secretion of catecholamines altered adrenoreceptor system sensitivity in Langerhans islands with the subsequent decrease in insulin production. Content of cAMP in brain of resuscitated dogs as compared with controls was increased less drastically.

[Lipid peroxidation in patients with iron deficiency anemia complicated by frequent acute respiratory diseases]. / Protsessy perekisnogo okisleniia lipidov u bol'nykh zhelezodefitsitnoi anemiei s chastymi ostrymi respiratornymi zabolevaniiami.

Lipid peroxidation (diene conjugates and lipofuscinoid pigments) and activity of antiperoxidation defense enzymes (catalase, glutathione reductase, glucose 6-phosphate dehydrogenase) were studied in 55 patients with iron deficiency anemia. It was found that in uneventful iron deficiency anemia the above parameters change insignificantly in contrast with anemic patients prone to acute respiratory infections. The latter demonstrate enhancement of lipid peroxidation in spite of high activity of glutathione reductase and glucose 6-phosphate dehydrogenase.

[Disruption of carbohydrate metabolism regulation and processes connected with it in the recovery period after clinical depth of various duration]. / Narushenie reguliatsii uglevodnogo obmena i sopriazhennykh s nim protsessov v vosstanovitel'nom periode posle klinicheskoi smerti raznoi prodolzhitel'nosti.

Hyperglycemia, caused by elevated levels of glucagon simultaneously with inhibition of the hypophysis-hypothalamus-adrenal system, was developed in dogs after clinical death of various duration within the first hour of recirculation. Hyperlactemia produced under these conditions contributed to an increase in catabolism of purines followed by stimulation of lipid peroxidation in erythrocyte membranes. Beginning from the end of the first day of the postresuscitation period the intensity of these processes was decreased and gradually reached the control values.

[The general biological principles of the development of complications in the postoperative period of acute peritonitis and the expediency of hemosorption]. / Obshchebiologicheskie zakonomernosti formirovaniia oslozhenii v posleoperatsionnom periode ostrogo peritonita i tselesoobraznost' gemosorbtsii.

The dynamic study of a number of clinical and laboratory findings in 107 patients with acute peritonitis have shown that with the current complex infusion therapy the onset of postoperative complications is to a great extent mediated by high toxin level--medium molecular mass polypeptide, inhibiting the processes of protein synthesis and consequently causing changes in the relationship between adaptation compensatory reactions, which demonstrates the necessity of additional active detoxicating therapy, i.e. hemosorption (HS). HS was performed to 126 patients and its efficacy in pronounced toxemia was established. The data obtained make it possible to consider HS as an effective means preventing the onset of postoperative complications in acute peritonitis.

[The effect of dexamethasone on the metabolism of the hormone regulators of carbohydrate metabolism in the postresuscitation period]. / Vliianie deksametazona na obmen gormonov--reguliatorov metabolizma uglevodov v postreanimatsionnom periode.

Administration of dexamethasone (dexasone) to dogs against the background of dysfunction of the hypothalamic-pituitary-adrenal system (HPAS) developing in the first three days of the postresuscitation period causes diverse changes in secretion of hormones of the pancreas. At a relative normalization of HPAS functioning noted 7 days after resuscitation the drug was shown to decrease intensity of glycolysis and processes of lipid peroxidation.

[Metabolic and immunologic disorders in the pathogenesis of iron deficiency anemia and its complications]. / Metabolicheskie i immunologicheskie narusheniia v patogeneze zhelezodefitsitnoi anemii i ee oslozhnenii.

Sixty-five patients with iron deficiency anemia have been examined for lipid peroxidation, antiperoxidation protection and immunoreactivity. It was noted that progression of the disease was associated with developing hypoxia followed by enhancement of lipid peroxidation and derangement of immunity. Origin of complications may be related to abnormal lipid peroxidation and defects in immunity.

[Impairment of glutathione metabolism in the liver of resuscitated rats and its correction]. / Narushenie obmena gliutationa v pecheni reanimirovannykh krys i ego korrektsiia.

Elevated synthesis of glutathione in liver tissue of rats after resuscitation did not exclude its deficiency in the animals. Administration of exogenous glutathione before asphyxia decreased the rate of structural membrane lipids peroxidation as well as contributed to more effective function of energy generation systems.

[Role of lipid peroxidation in damage to brain neurons during ischemia and in the postischemic period]. / Rol' perekisnogo okisleniia lipidov v povrezhdenii neironov mozga pri ishemii i v postishemicheskom periode.

It has been demonstrated in experiments on rats that highly activated lipid peroxidation in brain tissue during ischemia and early postischemic period gives rise to injuries of membrane structures of neurons and to formation of lysosomes that subsequently aggravate neuronal destruction.

[Comparative characteristics of methods of evaluation of plasma toxicity and severity of toxemia in acute diffuse peritonitis]. / Sravnitel'naia kharakteristika metodov otsenki toksichnosti plazmy krovi i tiazhesti intoksikatsii pri ostrom razlitom peritonite.

Experimental and clinical investigations have established the method of biological testing on mice and the leukocyte index of intoxication to be objective and reliable criteria for the estimation of the blood plasma toxicity and the degree of intoxication.