[The significance of endometrial cells in the cervical smear]. / De betekenis van endometriumcellen in de cervixuitstrijk.

Presence of atypical endometrial cells in a cervical smear is quite unusual; but if they are found the woman needs extra attention because of the risk of adenocarcinoma of the uterus. Postmenopausal women sometimes also have endometrial cells without atypia in the cervical smear, as a sign of endometrial pathology. We conducted a retrospective follow-up study of these women. From 1978 to 1989, 52 smears from a total of about 50,000 postmenopausal women were classified as Pap IIIA, due to the presence of normal endometrial cells. Histological follow-up was performed in 25 cases and 3 times an adenocarcinoma of the endometrium was diagnosed (6%). The smears from 142 women (pre- and postmenopausal) contained atypical endometrial cells and therefore were classified as Pap IIIA or higher. Histological follow-up was performed in 104 cases. In 48% (n = 68) an adenocarcinoma was diagnosed. In 75% of these cases (n = 51) the atypical cells were graded as severe or worse (> or = Pap IIIB). Cervical smears are not taken to detect pathology of the endometrium, but whenever atypical cells are found in the smear there is a strong indication for further (gynaecological) examination.

Histopathological findings in placentae from patients with intra-uterine fetal death and anti-phospholipid antibodies.

Anti-phospholipid antibodies are associated with first trimester abortions and late intra-uterine fetal death. The histopathology of 47 placentae from 45 women with intra-uterine fetal death, including 16 patients with anti-phospholipid antibodies, was studied in order to detect potential differences between placentae from women with and without these antibodies. Thirteen patients had systemic lupus erythematosus or lupus-like disease, including 6 women with anti-phospholipid antibodies. In placentae from patients with anti-phospholipid antibodies, a decrease in vasculo-syncytial membranes, fibrosis mainly in infarcted areas, hypovascular villi and thrombosis or infarction was seen significantly more often than in placentae from women without these antibodies. Of 17 placentae from 16 patients with anti-phospholipid antibodies, only 3 did not demonstrate signs of thrombosis or infarction. Thrombosis/infarction was significantly associated with a decrease in vasculo-syncytial membranes, fibrosis, hypovascular villi and an increase in syncytial knots. These findings are most likely to be the result of prolonged hypoxia due to thrombosis or infarction. It is concluded that thrombosis or infarctions are prominent features in placenta from patients with anti-phospholipid antibodies and intra-uterine fetal death. Consequently, antithrombotic treatment during pregnancy forms a rational approach in these patients.

[Cervix smears with mild atypia classified as Pap-class IIIA: results of a changed policy]. / Cervixuitstrijken met geringe atypie ingedeeld in Pap-klasse IIIA: resultaten van een gewijzigd beleid.

To evaluate the changed policy regarding cervical smears with mild atypia in the Netherlands (before 1988 classified as Pap II, thereafter as Pap IIIA), an descriptive study was carried out in the laboratory of gynaecological cytology Cyt-U-Universitair (University of Utrecht). All women who in 1988 had a first smear with mild atypia were included. After a follow-up period of 2 years the final diagnosis was noted. The results of the follow-up of cervical smears with mild atypia were compared with the follow-up results of moderate atypia. A selection was made of 477 women. In 55% of the cases no dysplasia was found during the 2 years of follow-up. In 12% of the cases severe dysplasia, carcinoma in situ or carcinoma was found. Compared with the smears with moderate atypia the dysplasia in the follow-up of mild atypia led to fewer cases of proven dysplasia. In addition the dysplasia in these cases was of a lower grade. The group of women referred to the gynaecologist after the smear with mild atypia was remarkably large (30%). As the results show, the policy of careful follow-up of women with mild atypia in the cervical smear has been a good one. It implies classifying mild atypia as Pap IIIA. As many women (55%) do not display cervical dysplasia within a 2 year follow-up period, the policy of making a repeat smear before referring appears justified.

Leiomyoma of the distal oesophagus mimicking achalasia.

An unusual case of a patient with symptoms suggestive of oesophageal achalasia is described. Most oesophageal tumour growths causing secondary achalasia are associated with malignant tumours. This patient had a large oesophageal leiomyoma closely mimicking achalasia. Treatment consisted of oesophagectomy by laparotomy and right-sided thoracotomy. A gastric tube was constructed with a cervical oesophago-gastrostomy. The patient responded well to the treatment and left the hospital after 13 days. Five other cases of benign oesophageal tumours inducing achalasia-like symptoms could be traced. Three of these were leiomyomas.

Malignant mixed müllerian tumour of the fallopian tube.

We report two cases of primary heterologous malignant mixed Müllerian tumour of the Fallopian tube. One of these was bilateral, a finding which, as far as we know, has not been reported before.

Immature teratomas in children.

In a retrospective study comprising 216 germ-cell tumours occurring in children from birth to the age of 18 years, 27 immature teratomas were found at a variety of sites. Seventeen of these were curatively treated by means of one operation. Only two patients died as a direct result of tumour growth. Recurrences and metastases often proved to be treatable. In ovarian tumours grading was of considerable prognostic importance. The term malignant teratoma, which is sometimes used to describe these tumours, is confusing and should be avoided.

Sertoli cell and sertoli-Leydig cell tumors of the ovary. A report of three cases with ultrastructural findings.

Three tumors of the ovary containing Sertoli cells were studied by light and electron microscopy. Two of these tumors were well-differentiated neoplasms with epithelial cells often forming tubules. These cells were cylindrically shaped, contained round to oval nuclei and stood on a thin basement membrane. The cytoplasm was fibrillary and showed rough and smooth endoplasmic reticulum, lipid droplets and secretory granules. At the luminal borders the cells were often irregular and displayed apocrine-like activity. Having compared our data with results of studies from the literature of normal Sertoli cells, Sertoli cell adenomas of the testis and cells from other parts of the male reproductive system and those of normal ovarian stroma, we conclude that the Sertoli cell is most probably the cell of origin of these tumors. The third tumor was undifferentiated with a sarcomatoid appearance and contained islands of cartilage, which we consider to be metaplastic.