ABSTRACT
Relatamos o caso do paciente do sexo masculino, de 27 anos, com urticaria cronica como manifestacao de vasculite necrosante cutanea, associada a artrite, febre, emagrecimento e hipocomplementemia. A sindrome caracterizada neste paciente e semelhante aos casos previamente relatados como "vasculite hipocomplementemica", "vasculite necrosante associada a urticaria cronica" e "vasculite urticariforme". Apresentamos revisao de literatura e discussao do diagnostico diferencial e tratamento. Acreditamos que essa nova sindrome constitui uma subpopulacao distinta de patologia colageno-vascular
Subject(s)
Adult , Humans , Male , Urticaria , Vasculitis, Leukocytoclastic, Cutaneous , Diagnosis, DifferentialSubject(s)
Immunity, Cellular , Schistosomiasis/immunology , Adolescent , Adult , Child , Female , Humans , Hypersensitivity, Delayed , In Vitro Techniques , Lymphocyte Activation , Male , Middle Aged , Rosette Formation , Skin TestsABSTRACT
The thymus-dependent immunity of 42 patients with SCCC was evaluated by: delayed cutaneous reactions to ubiquitous antigens, DNCB sensitization, and lymphocyte response to PHA. In addition, T and B lymphocytes were detected in peripheral blood and in tumor sections, by adherence to E and HEAC. Depressed CMI was more intense in patients with disseminated disease, although a premature impairment of CMI was observed in some patients with initial-stage tumors. The absolute number of peripheral T lymphocytes showed association with both cutaneous reactions and PHA response. However, there appeared to be no significant correlation between the stage of the tumor and the pattern of adherence of E or HEAC to the biopsies.
Subject(s)
Carcinoma, Squamous Cell/immunology , Immunity, Cellular , Uterine Cervical Neoplasms/immunology , Adult , Aged , B-Lymphocytes/analysis , Female , Humans , Middle Aged , Neoplasm Staging , T-Lymphocytes/analysisSubject(s)
Immunotherapy/methods , Neoplasms/therapy , BCG Vaccine/therapeutic use , Humans , Neoplasms/immunologyABSTRACT
Cell-mediated immunity (CMI) was evaluated in 82 patients with non-lymphoid tumors by in vivo and in vitro methods. These included skin test with ubiquitous antigens, 2,4 dinitrochlorobenzene (DNCB) sensitization, determination of T and B peripheral blood lymphocytes, and lymphocyte response to phytohemagglutinin (PHA). The patients were divided into two groups: those with localized and those with disseminated disease (LD and DD). The patients with LD showed no significant differences in CMI when compared with normal controls. The patients with DD showed various defects in CMI when compared with controls and patients with LD. There were significant differences in the response to DNCB, and streptokinase-streptodornase (SK-SD) was the most discriminative of the skin-test antigens. The response to PHA was greatly depressed in patients with DD, whether in the presence of autologous or homologous plasma; in some patients a factor inhibiting to blastogenesis was detected in the serum. In patients with DD, a T-cell lymphopenia was observed. These data showed a correlation between immunocompetence and clinical stage.
