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1.
BMC Neurol ; 12: 75, 2012 Aug 16.
Article in English | MEDLINE | ID: mdl-22897903

ABSTRACT

BACKGROUND: Although the development of early-onset dementia is a radical and invalidating experience for both patient and family there are hardly any non-pharmacological studies that focus on this group of patients. One type of a non-pharmacological intervention that appears to have a beneficial effect on cognition in older persons without dementia and older persons at risk for dementia is exercise. In view of their younger age early-onset dementia patients may be well able to participate in an exercise program. The main aim of the EXERCISE-ON study is to assess whether exercise slows down the progressive course of the symptoms of dementia. METHODS/DESIGN: One hundred and fifty patients with early-onset dementia are recruited. After completion of the baseline measurements, participants living within a 50 kilometre radius to one of the rehabilitation centres are randomly assigned to either an aerobic exercise program in a rehabilitation centre or a flexibility and relaxation program in a rehabilitation centre. Both programs are applied three times a week during 3 months. Participants living outside the 50 kilometre radius are included in a feasibility study where participants join in a daily physical activity program set at home making use of pedometers. Measurements take place at baseline (entry of the study), after three months (end of the exercise program) and after six months (follow-up). Primary outcomes are cognitive functioning; psychomotor speed and executive functioning; (instrumental) activities of daily living, and quality of life. Secondary outcomes include physical, neuropsychological, and rest-activity rhythm measures. DISCUSSION: The EXERCISE-ON study is the first study to offer exercise programs to patients with early-onset dementia. We expect this study to supply evidence regarding the effects of exercise on the symptoms of early-onset dementia, influencing quality of life. TRIAL REGISTRATION: The present study is registered within The Netherlands National Trial Register (ref: NTR2124).


Subject(s)
Alzheimer Disease/epidemiology , Alzheimer Disease/rehabilitation , Cognition Disorders/epidemiology , Cognition Disorders/rehabilitation , Dementia/epidemiology , Dementia/rehabilitation , Exercise Therapy/statistics & numerical data , Aged , Aged, 80 and over , Exercise Therapy/methods , Feasibility Studies , Humans , Male , Middle Aged , Netherlands/epidemiology , Prevalence , Treatment Outcome
2.
Arch Phys Med Rehabil ; 91(1): 123-8, 2010 Jan.
Article in English | MEDLINE | ID: mdl-20103406

ABSTRACT

UNLABELLED: Horstman AM, Gerrits KH, Beltman MJ, Koppe PA, Janssen, TW, de Haan A. Intrinsic properties of the knee extensor muscles after subacute stroke. OBJECTIVE: To characterize muscle properties of paretic lower-limb (PL) and nonparetic lower-limb (NL) knee extensors in patients with subacute stroke. DESIGN: Case-control study. SETTING: Rehabilitation center research laboratory. PARTICIPANTS: Patients with subacute stroke (n=14) and able-bodied age-matched control subjects (n=12). INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Half relaxation times (HRTs) and maximal rates of torque development (MRTDs) were assessed as indicators of contractile speed using both voluntary and electrically evoked contractions. Moreover, changes in torque were measured during a fatigue protocol (35 electrically evoked intermittent contractions; 1.5s on, 2s off) and recovery. RESULTS: No differences among groups were found for normalized MRTDs during electrically evoked contractions (P=.117). However, during voluntary contractions both PLs (53% of control, P=.022) and NL (71% of control, P<.001) had significantly lower MRTD compared with control. Both PL (134% of control, P=.001) and NL (123% of control, P=.032) had significantly higher HRTs than control, indicating muscle slowing in patients with subacute stroke. PLs fatigued more and faster than control (P=.011) and both PL and NL recovered slower (P<.001). CONCLUSIONS: The changes in HRTs and fatigue suggest adaptations in muscle properties toward slower, more fatigable muscle shortly after stroke. The inability to make use of contractile speed because of impaired neural activation seems the most limiting factor during the initial phase of torque development in PL. Thus, besides strengthening, muscle endurance and speed should also be addressed during rehabilitation.


Subject(s)
Muscle, Skeletal/physiopathology , Paresis/physiopathology , Stroke/physiopathology , Aged , Case-Control Studies , Electric Stimulation , Female , Humans , Knee , Lower Extremity , Male , Middle Aged , Muscle Contraction/physiology , Muscle Fatigue/physiology , Muscle Relaxation/physiology , Paresis/rehabilitation , Stroke Rehabilitation
3.
Arch Phys Med Rehabil ; 90(9): 1557-64, 2009 Sep.
Article in English | MEDLINE | ID: mdl-19735784

ABSTRACT

OBJECTIVE: To identify a possible relationship among chronic poststroke shoulder pain (PSSP), scapular resting pose, and shoulder proprioception. DESIGN: Case-control study. SETTING: Rehabilitation center. PARTICIPANTS: A total of 21 inpatients with stroke and 10 healthy control subjects. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Orientations of both the contralateral and ipsilateral (ie, paretic and nonparetic) shoulders during rest in degrees, angular displacement (degrees) for threshold to detection of passive motion (TDPM) tests, and absolute error (degrees) for passive reproduction of joint position (PRJP) tests. RESULTS: The contralateral shoulder of patients with PSSP showed more scapular lateral rotation and larger TDPM and PRJP scores than both patients without PSSP and control subjects. Additionally, the contralateral shoulder of patients with deteriorated proprioception showed more scapular lateral rotation than control subjects, whereas their ipsilateral shoulder showed more scapular lateral rotation than both control subjects and patients with good proprioception. CONCLUSIONS: A clear relation among affected shoulder kinematics, affected proprioception, and PSSP was found. In determining the risk of developing PSSP, attention should be paid to a patients shoulder proprioception and kinematics. If both are altered after stroke, this could worsen the initial pathology or cause secondary pathologies and thus initiate a vicious circle of repetitive soft tissue damage leading to chronic PSSP. Additionally, more attention should be paid to the ipsilateral (ie, nonparetic) shoulder because it could be used in determining the risk of developing PSSP in the contralateral (ie, paretic) shoulder.


Subject(s)
Pain/physiopathology , Pain/psychology , Proprioception , Shoulder Joint/physiopathology , Stroke/physiopathology , Stroke/psychology , Adult , Aged , Biomechanical Phenomena , Case-Control Studies , Female , Humans , Male , Middle Aged , Pain/etiology , Rehabilitation Centers , Scapula/physiopathology , Stroke/complications
4.
Arch Phys Med Rehabil ; 90(3): 480-7, 2009 Mar.
Article in English | MEDLINE | ID: mdl-19254615

ABSTRACT

OBJECTIVE: (1) To examine the isometric strength, speed, and fatigue resistance of the knee extensors of the paretic limb and nonparetic limb in patients with stroke and compare these with able-bodied subjects. (2) To relate the contractile properties with different indices of functional performance. DESIGN: Case-control study. SETTING: Rehabilitation center research laboratory. PARTICIPANTS: Eighteen stroke patients and 10 able-bodied controls. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Maximal voluntary torque (MVT), maximal rate of torque development, time to maximal rate of torque development, half relaxation time ((1/2)RT), and fatigue index. Scores on the Functional Ambulation Category scale, Berg Balance Scale, and Rivermead Mobility Index as well as distance walked during the six-minute walk test were obtained. RESULTS: MVT of the paretic leg was lower than of the nonparetic leg (P<.05), and both limbs had lower MVT than controls (P<.05). Both the paretic and the nonparetic leg showed longer (1/2)RT compared with controls (P<.05). The fatigue index was reduced in the paretic leg (P<.05) but not in the nonparetic leg compared with controls. MVT and fatigue index of the paretic leg were related to indices of functional performance (r=0.49-0.64; P<.05). CONCLUSIONS: Apart from bilateral weakness, knee extensors in patients with stroke showed a lower rate of torque development and relaxation (both paretic and nonparetic leg) and lower fatigue resistance (paretic leg only) than controls, which in part may be a consequence of changes within the muscles. Strength and fatigue resistance relate to functional performance, indicating that these muscle properties should be addressed during rehabilitation. However, future research is needed to elucidate the efficacy of exercise programs.


Subject(s)
Isometric Contraction , Knee/physiopathology , Muscle, Skeletal/physiopathology , Stroke Rehabilitation , Stroke/physiopathology , Adult , Aged , Case-Control Studies , Female , Humans , Male , Middle Aged , Movement , Muscle Strength , Young Adult
5.
Arch Phys Med Rehabil ; 89(3): 463-9, 2008 Mar.
Article in English | MEDLINE | ID: mdl-18295624

ABSTRACT

OBJECTIVE: To evaluate whether leg cycling training in subjects with chronic stroke can improve cycling performance, aerobic capacity, muscle strength, and functional performance and to determine if electric stimulation (ES) to the contralateral (paretic) leg during cycling has additional effects over cycling without ES. DESIGN: A randomized controlled trial, with a partial double-blind design. SETTING: A rehabilitation center. PARTICIPANTS: Twelve stroke patients (range, 18-70 y), more than 5 months poststroke, with lower-extremity hemiparesis. INTERVENTION: Subjects were randomly assigned to groups that performed cycling exercise, one with ES evoking muscle contractions and a control group with ES not evoking muscle contractions. Subjects, blinded for group assignment, trained twice a week for 6 weeks. MAIN OUTCOME MEASURES: Changes in aerobic capacity and maximal power output, functional performance, and lower-limb muscle strength. RESULTS: Aerobic capacity and maximal power output significantly increased by 13.8%+/-19.1% and 38.1%+/-19.8%, but muscle strength was not significantly enhanced after training. Functional performance improved (ie, scores on the Berg Balance Scale increased by 6.9%+/-5.8% (P=.000) and the six-minute walk test improved by 14.5%+/-14.1% (P=.035). There was no significant effect on the Rivermead Mobility Index (P=.165). Training-induced changes were not significantly different between the 2 groups. Changes in cycling performance and aerobic capacity were not significantly related to changes in functional performance. CONCLUSIONS: This study showed that a short cycling training program on a semirecumbent cycle ergometer can markedly improve cycling performance, aerobic capacity, and functional performance of people with chronic stroke. The use of ES had no additional effects in this specific group of subjects with chronic stroke.


Subject(s)
Bicycling/physiology , Electric Stimulation/methods , Exercise Therapy/methods , Muscle Strength/physiology , Stroke Rehabilitation , Adolescent , Adult , Aged , Chronic Disease , Double-Blind Method , Exercise , Female , Follow-Up Studies , Humans , Male , Middle Aged , Probability , Recovery of Function , Reference Values , Rehabilitation Centers , Risk Assessment , Severity of Illness Index , Stroke/diagnosis , Treatment Outcome
6.
Arch Phys Med Rehabil ; 89(2): 333-8, 2008 Feb.
Article in English | MEDLINE | ID: mdl-18226659

ABSTRACT

OBJECTIVE: To investigate position sense and kinesthesia of the shoulders of stroke patients. DESIGN: Case-control study. SETTING: A rehabilitation center. PARTICIPANTS: A total of 22 inpatients with stroke and 10 healthy control subjects. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Angular displacement (in degrees) for threshold to detection of passive motion (TDPM) tests and absolute error (in degrees) for passive reproduction of joint position tests. RESULTS: For patients, the TDPM for internal and external rotation was significantly higher for both the contralateral (paretic) side (internal, 7.92 degrees +/-7.19 degrees ; external, 8.46 degrees +/-8.87 degrees ) and the ipsilateral (nonparetic) side (internal, 4.86 degrees +/-5.03 degrees ; external, 6.09 degrees +/-9.15 degrees ) compared with the control group (internal, 1.83 degrees +/-1.09 degrees ; external, 1.71 degrees +/-.85 degrees ). Also, for internal rotation, TDPM was significantly higher for patients on the contralateral side compared with the ipsilateral side. For passive reproduction of joint position tests, no differences were found. CONCLUSIONS: Both the contralateral and ipsilateral shoulders of stroke patients showed impaired TDPM. Passive reproduction of joint position does not seem to be affected as a result of a stroke. The control of the muscle spindles and central integration or processing problems of the afferent signals provided by muscle spindles might cause these effects.


Subject(s)
Proprioception/physiology , Shoulder Joint/physiopathology , Stroke/physiopathology , Analysis of Variance , Case-Control Studies , Female , Humans , Male , Middle Aged , Range of Motion, Articular , Rotation , Statistics, Nonparametric
7.
Am J Phys Med Rehabil ; 84(2): 97-105, 2005 Feb.
Article in English | MEDLINE | ID: mdl-15668557

ABSTRACT

OBJECTIVE: To evaluate the assumption that shoulder kinematic patterns of the ipsilateral, nonparetic shoulder in hemiplegia are similar to kinematics recorded in a healthy population. DESIGN: Case control study of a convenience sample of ten patients with hemiplegia due to stroke in the subacute phase compared with a control group of similar age. Three-dimensional positions of the scapula and humerus were measured and expressed in Euler angles as a function of active arm elevation in the frontal and sagittal plane and during passive humeral internal/external rotation at an elevation angle of 90 degrees in the frontal and sagittal plane. RESULTS: Compared with controls, in the ipsilateral shoulder of patients, we found both a statistically significant diminished scapular protraction during elevation in the sagittal plane (35 +/- 5 vs. 51 +/- 8 degrees at 110 degrees of humeral elevation) and humeral external rotation during arm elevation in the frontal plane (51 +/- 7 vs. 69 +/- 14 degrees at 110 degrees of humeral elevation). Maximal passive humeral external rotation was found to be impaired in the frontal (64 +/- 13 vs. 98 +/- 14 degrees) and sagittal planes (65 +/- 11 vs. 94 +/- 12 degrees). In addition, there was significantly diminished anterior spinal tilt during humeral internal rotation (-5 +/- 10 vs. -20 +/- 9 degrees) and diminished posterior spinal tilt during external rotation in the frontal plane (-14 +/- 8 vs. -3 +/- 6 degrees). Maximal thoracohumeral elevation in patients was significantly impaired (126 +/- 12 vs. 138 +/- 8 degrees). CONCLUSION: Clear kinematic changes in the ipsilateral shoulder in patients with hemiplegia were found, indicating underlying alterations in muscle contraction patterns. The cause remains speculative. These results suggest that the ipsilateral shoulder should not be considered to function normally beforehand.


Subject(s)
Hemiplegia/physiopathology , Shoulder Joint/physiopathology , Stroke/complications , Adult , Aged , Biomechanical Phenomena , Case-Control Studies , Female , Hemiplegia/etiology , Humans , Male , Middle Aged , Range of Motion, Articular/physiology , Scapula/physiopathology
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