ABSTRACT
Neural probes for intracortical neuromodulation in the brain have advanced with the developments in micro- and nanofabrication technologies. Most of these technologies for the intracortical stimulation have relied on the direct electrical stimulation via electrodes or arrays of electrodes. Generating electric fields using time-varying magnetic fields is a more recent neuromodulation technique that has proven to be more specifically effective for the intracortical stimulation. Additionally, current-actuated coils require no conductive contact with tissues and enable precise tailoring of magnetic fields, which are unaffected by the non-magnetic nature of the biological tissue and encapsulation layers. The material and design parameter space for such micro-coil fabrication can be optimized and tailored to deliver the ideal performance depending on the parameters needed for operation. In this work, we review the key requirements for implantable microcoils including the probe structure and material properties and discuss their characteristics and related challenges for the applications in intracortical neuromodulation.
ABSTRACT
We have demonstrated a printed electronic tag that monitors time-integrated sensor signals and writes to nonvolatile memories for later readout. The tag is additively fabricated on flexible plastic foil and comprises a thermistor divider, complementary organic circuits, and two nonvolatile memory cells. With a supply voltage below 30 V, the threshold temperatures can be tuned between 0 °C and 80 °C. The time-temperature dose measurement is calibrated for minute-scale integration. The two memory bits are sequentially written in a thermometer code to provide an accumulated dose record.
