[Results and the prospects of use of the new chemical preparation polyplatillene with antineoplastic and antiviral properties]. / Rezul'taty i perspektivy primeneniia novogo khimiopreparata poliplatillena, obladaiushchego protivoopukholevymi i protivovirusnymi svoístvami.

Ten years experience of the polyplatillene clinical application and experimental study is summarized. Results of treatment of 689 inner organs cancer patients stage IV, I-IV clinical groups. The advantages of polyplatillene versus others platinum group chemopreparations are shown. Manufacturing difficulties, mistakes and perils of the preparation application are pointed out. The direct dose-dependence of results is shown. Possibilities of polyplatillene application in biotechnology, radiology, virusology as a regulator of the cell division, viral replication and their interaction with a cell is shown.

[The effect of application-sorption therapy on dynamics of activity of molecular carriers of electrons of the energetic and detoxifying systems of cells in experimental burn disease]. / Vliianie applikatsionno-sorbtsionnoi terapii na dinamiku aktivnosti molekuliarnykh perenoschikov élektronov énergeticheskoi i detoksitsiruiushchei sistem kletki pri éksperimental'noi ozhogovoi bolezni.

Integral free radical state, paramagnetic enzyme complexes of nonheme iron with sulfur- and nitrogen-containing ligands in mitochondria and heme iron in microsomes as well as metalloenzymes of blood plasma ceruloplasmin and transferrin were studied in dynamics of burn disease in rats. Significant decrease in content of reduced ferrosulfur proteins in mitochondrial energy system was observed in kidneys within the second day after the burns and in liver tissue within the 14-21 days after the failure which correlated with reduction of cytochrome P-450 oxidized form. Development of paramagnetic nitrosyl complexes of heme and nonheme iron, specific for hypoxia, were detected in the impaired muscle tissue. Increase in tissue hypoxia was accompanied by decrease in content of transferrin and by elevation in the antioxidant activity of blood plasma. Application of local adsorption after early excision of burns crust contributed to normalization of both metabolism in the impaired tissues and in activity of the electron transport chain in liver and kidney tissues. Therefore, local adsorption therapy may be considered as an alternative procedure in sorptional detoxication of burns.

[Prospects for using platinum coordination compounds possessing antitumor activity]. / Perspektivy primeneniia koordinatsionnykh soedinenii platiny, obladaiushchikh protivoopukholevoi aktivnost'iu.

The review presents a complete analysis of studies on experimental and clinical application of platinum complexes with special reference to cis-dichlorodiamminoplatinum, both separately and in combination with other chemotherapeutic preparations. Platinum complexes show their highest antiblastic activity in treatment of ovarian, testicular, lung tumours and those located in the head and neck regions as well as of the bladder cancer and tumours of the other localizations resistant to the action of alkylating agents and other preparations. The clinical material is systematized so that it is possible on the basis of the analysis performed to choose an optimum regime for treating different tumours by platinum complexes.