ABSTRACT
Langerhans cells (LC) were identified and quantitated in non-inflamed keratoacanthoma (KA), inflamed KA, non-inflamed squamous cell carcinoma (SCC), and inflamed SCC, by their content of S100 protein. The number of LCs per high-power field was markedly increased in inflamed KA when compared to the other groups. Using similar methods on frozen sections, the expression of HLA-DR was identified on keratinocytes in KA in areas of inflammation but not in other lesions under study. We hypothesize that increased numbers of LCs in inflamed KA are part of the process which results in tumor regression.
Subject(s)
Carcinoma, Squamous Cell/pathology , Keratoacanthoma/pathology , Langerhans Cells/analysis , S100 Proteins/analysis , Skin Diseases/pathology , Skin Neoplasms/pathology , Carcinoma, Squamous Cell/diagnosis , Diagnosis, Differential , Humans , Inflammation/pathology , Keratoacanthoma/diagnosis , Langerhans Cells/ultrastructure , Skin Diseases/diagnosis , Skin Neoplasms/diagnosisABSTRACT
Intravenous vasopressin is a commonly used modality for control of bleeding esophageal varices. The development of ischemic cutaneous complications is a recently described entity. In previous reports, cutaneous necrosis has occurred at sites of extravasation, at or proximal to intravenous catheter sites, or at isolated pressure points. We review the literature on vasopressin-induced cutaneous reactions and report a case of cutaneous necrosis and bulla formation in which multiple bullae formed during vasopressin therapy at sites distant from direct intravenous flow.
