1.
Farmakol Toksikol
; 38(2): 210-4, 1975.
Article
in Russian
| MEDLINE
| ID: mdl-1227893
ABSTRACT
Less pronounced intensity of extrapyramidal hyperkineses and aggravation of motor disturbances in patients with diffuse sclerosis occurring under the effect of tegretol prompted the authors to study the action of this drug on the course of experimental allergic encephalomyelitis. Daily administration of tegretol in a dose of 375 mg/kg retarded the development of the affection and produced a marked adynamia in the animals. Slowing down of the dominant rhythm and depression of its amplitude were recorded on the EEG. Shifts in the potassium and sodium content and reduced brain cholesterase activity were noted. The authors ascribe these changes to a mediated action of tegretol upon deep-seated cerebral structures.
Subject(s)
Carbamazepine/pharmacology , Encephalomyelitis, Autoimmune, Experimental/drug therapy , Administration, Oral , Animals , Brain/drug effects , Brain/enzymology , Brain Chemistry , Cholinesterases/metabolism , Drug Evaluation, Preclinical , Electroencephalography , Enzyme Activation/drug effects , Female , Guinea Pigs , Male , Potassium/analysis , Seizures/chemically induced , Sodium/analysis , Spinal Cord/analysis , Time Factors
2.
Zh Nevropatol Psikhiatr Im S S Korsakova
; 74(8): 1121-4, 1974.
Article
in Russian
| MEDLINE
| ID: mdl-4417287
Subject(s)
Encephalitis/diagnosis , Encephalomyelitis/diagnosis , Adult , Chronic Disease , Diagnosis, Differential , Encephalomyelitis/complications , Female , Fever , Fundus Oculi , Hepatolenticular Degeneration/diagnosis , Humans , Hyperkinesis/etiology , Hypesthesia/etiology , Multiple Sclerosis/diagnosis , Pain , Remission, Spontaneous
3.
Zh Nevropatol Psikhiatr Im S S Korsakova
; 72(12): 1797-800, 1972.
Article
in Russian
| MEDLINE
| ID: mdl-4663372
4.
Vopr Med Khim
; 16(5): 518-24, 1970.
Article
in Russian
| MEDLINE
| ID: mdl-4257161