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J Neurochem ; 77(3): 896-903, 2001 May.
Article in English | MEDLINE | ID: mdl-11331418

ABSTRACT

In the gustatory system, the recognition of sugars, amino acids and bitter-tasting compounds is the function of specialized G protein-coupled receptors. Recently, two members of novel subfamily of G protein-coupled receptors were proposed to function as taste receptors based on their specific expression in taste receptor cells. Here, we report the identification of a third member, T1R3, of this family of receptors. T1R3 maps near the telomere of mouse chromosome 4 rendering it a candidate for the Sac locus, a primary determinant of sweet preference in mice. Consistent with its candidacy for the Sac locus, T1R3 displays taste receptor cell-specific expression. In addition, taster and non-taster strains of mouse harbor different alleles of T1R3.


Subject(s)
Receptors, Cell Surface/analysis , Receptors, G-Protein-Coupled , Taste , Amino Acid Sequence , Animals , Chromosome Mapping , Gene Expression , In Situ Hybridization , Mice , Mice, Inbred C57BL , Molecular Sequence Data , Olfactory Mucosa/chemistry , Protein Sorting Signals , Rats , Receptors, Cell Surface/chemistry , Receptors, Cell Surface/genetics , Sequence Alignment , Taste/genetics , Taste Buds/chemistry , Tongue/cytology
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