ABSTRACT
Endogenous interferon was produced in animals in response to the administration of tobacco mosaic virus (TMV), tilorone and sodium nucleinate. The relationship between interferon production and the kind of inducer and the route of its administration was studied. TMV was completely innocuous for Macaca rhesus monkeys and mice and caused no untoward effects in humans upon peroral administration. TMV, tilorone and sodium nucleinate given per os exerted a marked protective effect in mice against tick-borne encephalitis, eastern and western equine encephalomyelitis and influenza virus infections.
Subject(s)
Fluorenes/pharmacology , Interferon Inducers , Interferons/biosynthesis , Nucleic Acids/pharmacology , Tilorone/pharmacology , Tobacco Mosaic Virus , Administration, Oral , Animals , Drug Evaluation, Preclinical , Encephalitis, Tick-Borne/prevention & control , Encephalomyelitis, Equine/prevention & control , Humans , Influenza, Human/prevention & control , Interferon Inducers/administration & dosage , Interferons/urine , Mice , Nucleic Acids/administration & dosage , Rabbits , Tilorone/administration & dosageABSTRACT
Production of endogenic interferon in animals in responce to administration of tobaco mozaic virus, tilorone and sodium nucleinate was shown. Dependence of interferon production on the type of the inductor and the route of its administration was studied. Absolute innocuiuty of the tobaco mozaic virus for monkeys (macaco-resus) and mice, as well as the absence of any side effects in humans treated with it perorally was shown. The tobaco mozaic virus, tilorone and sodium nucleinate used perorally in treatment of experimental infections of mice caused by the viruses of East and West encephalomyelitis, influenza and tick encephalitis had a pronounced protective effect.
