ABSTRACT
AIM: To assess clinical efficiency and safety of ACE inhibitor prestarium (Servier, France) with specification of its effects on central and pulmonary hemodynamics, hepatic blood flow, indications in patients with chronic pulmonary heart (CPH). MATERIAL AND METHODS: 42 patients with chronic obstructive bronchitis (COB) complicated by CPH entered the trial. The patients were divided into two groups. Group 1 (n = 26) received standard therapy plus prestarium (2-4 mg/day), group 2 (n = 16) received only standard combined therapy. The examinees have undergone ultrasonic investigation of the heart and liver in Doppler modes, ECG monitoring, examination for external respiration function, lipid peroxidation activity, antioxidant blood defense. RESULTS: Group 1 demonstrated earlier positive response. It was found that improvement in functional class of cardiac failure induced by prestarium and less frequent episodes of arrhythmia directly correlated. Positive changes were stated in central and hepatic hemodynamics, systolic pressure in the pulmonary artery lowered more significantly than in the control group. CONCLUSION: If COB patients have symptoms of right ventricular failure, they are recommended to take prestarium in a daily dose 0.004 g for 4 weeks to improve intracardiac and hepatic hemodynamics, reduce systolic pressure in the pulmonary artery and number of prognostically unfavourable arrhythmic episodes.
Subject(s)
Angiotensin-Converting Enzyme Inhibitors/therapeutic use , Bronchitis, Chronic/complications , Hemodynamics/drug effects , Perindopril/therapeutic use , Pulmonary Heart Disease/drug therapy , Bronchitis, Chronic/physiopathology , Case-Control Studies , Chronic Disease , Humans , Middle Aged , Pulmonary Heart Disease/etiology , Pulmonary Heart Disease/physiopathology , Treatment OutcomeABSTRACT
52 patients with chronic obstructive bronchitis complicated by chronic decompensated cor pulmonale participated in the trial of dirotone. Effects on the clinical course and hemodynamics were assessed in the course and long-term treatment. A dirotone course was found to benefit central and pulmonary hemodynamics while a long-term dirotone treatment relieves symptoms of cardiac failure and raises life quality in the absence of negative effects on blood biochemistry, electrolytic balance and external respiration function.
