ABSTRACT
The changes were compared of the iron curve in children with chronic renal failure and with terminal renal failure after oral loading dose of ferrous sulphate. Flat curve of absorption was found in both groups of patients with increased stores of systemic iron and high values of transferrin saturation index (TSI). Steep iron curve and very good absorption were found in all children with decreased serum level of ferritin and decreased TSI. The curves of iron absorption at serum ferritin level 250-500 ng/ml pointed to impaired absorption and depended on the initial TSI value and initial iron level in the serum. No significant differences were found in the shape of iron curve depending on dialysing methods. Studying of the iron curve and values of TSI in certain patients makes easier the decision of administration of treatment with oral iron preparations even with increased values of TSI and ferritin in the serum.
Subject(s)
Iron/pharmacokinetics , Kidney Failure, Chronic/metabolism , Absorption , Administration, Oral , Adolescent , Child , Child, Preschool , Delayed-Action Preparations/administration & dosage , Delayed-Action Preparations/pharmacokinetics , Ferritins/blood , Ferrous Compounds/administration & dosage , Ferrous Compounds/pharmacokinetics , Humans , InfantABSTRACT
The prognostic significance of certain factors in the outcome of the haemolytic-uraemic syndrome (HUS) was evaluated. Seventy-three children with HUS were observed; 35 recovered without residual abnormalities, 6 had normal renal function with hypertension (HT) and/or urinary abnormalities, 5 had chronic renal failure, 1 child required chronic dialysis treatment, 4 children died of end-stage renal failure, and 22 died of acute renal failure (ARF). To identify the risk factors which influence prognosis, a logistic discrimination method was used to analyse the clinical and laboratory data. The logistic discrimination method established the role of independent factors which were linked together. The grouping of the patients in three different categories of favourable and unfavourable prognosis yielded conclusions concerning: (1) outcome of ARF survivors (2) recovery without sequelae or all other outcomes including death; (3) survival or death. The most important unfavourable factors for recovery of ARF survivors were HT and to a lesser degree cardiovascular (CV) disturbances; for recovery of the entire group, and for survival, the presence of CV disturbances was the worst prognostic factor. Among other factors were seasonal incidence, central nervous system disturbances, prodromal symptoms and age, which varied in their prognostic significance in the various groups.
Subject(s)
Hemolytic-Uremic Syndrome/physiopathology , Acidosis/complications , Acidosis/physiopathology , Age Factors , Anuria/complications , Anuria/physiopathology , Cardiovascular Diseases/complications , Cardiovascular Diseases/physiopathology , Child , Child, Preschool , Female , Humans , Hypertension/complications , Hypertension/physiopathology , Infant , Male , Prognosis , Renal Dialysis , Thrombocytopenia/complications , Thrombocytopenia/physiopathologySubject(s)
Kidney Failure, Chronic/drug therapy , Sulfamethoxazole/therapeutic use , Trimethoprim/metabolism , Trimethoprim/therapeutic use , Adolescent , Child , Child, Preschool , Drug Combinations/therapeutic use , Half-Life , Humans , Infant , Kinetics , Metabolic Clearance Rate , Sulfamethoxazole/metabolism , Trimethoprim/blood , Trimethoprim, Sulfamethoxazole Drug CombinationSubject(s)
Acute Kidney Injury/drug therapy , Kidney Failure, Chronic/drug therapy , Sulfamethoxazole/administration & dosage , Trimethoprim/administration & dosage , Adolescent , Body Weight , Child , Child, Preschool , Dose-Response Relationship, Drug , Drug Combinations/administration & dosage , Humans , Infant , Sulfamethoxazole/blood , Trimethoprim/blood , Trimethoprim, Sulfamethoxazole Drug CombinationSubject(s)
Catheterization/methods , Kidney Failure, Chronic/therapy , Renal Dialysis/methods , Subclavian Vein , Adolescent , Child , HumansSubject(s)
Acute Kidney Injury/diagnostic imaging , Adolescent , Child , Child, Preschool , Female , Humans , Infant , Kidney/diagnostic imaging , Male , UrographySubject(s)
Cloxacillin/blood , Creatinine/blood , Kidney Diseases/physiopathology , Kidney/physiopathology , Adolescent , Age Factors , Child , Child, Preschool , Humans , Infant , Kidney Diseases/bloodSubject(s)
Kidneys, Artificial , Acute Kidney Injury/therapy , Adolescent , Age Factors , Child , Child, Preschool , Humans , InfantSubject(s)
Kidney/abnormalities , Ureterocele/complications , Female , Humans , Infant , Ureterocele/surgeryABSTRACT
In the light of a retrospective analysis of 213 case records of infants with urinary tract infections, hyperbilirubinemia was disclosed in 19 cases. In 7 cases jaundice was the main cause of admission of these children to the hospital. It was observed mainly in the youngest age group up to 3 months. Jaundice was hemolytic in some cases and hepatic in others. Urinary tract malformations had no effect on the frequency of jaundice in urinary tract infection or on its intensity.
