[The effect of kavinton and korglycon on the central and cerebral hemodynamics of patients with an ischemic stroke in stenoses and occlusions of the major cerebral arteries]. / Vplyv kavintonu i korhlikonu na tsentral'nu ta tserebral'nu hemodynamiku u khvorykh na ishemichnyi insul't pry stenozakh i okliuziiakh mahistral'nykh arterii holovy.

Of the 40 patients, stenoses of major brain arteries were identified in 34, occlusions in 6, affection of two arteries in eleven patients, that of three arteries in 3 patients. The following disturbances in central hemodynamics were detected: arterial pressure getting higher, this referring also to the peripheral vascular resistance, hematocrit value, with the bloodflow in the arm-ear portion slowing down, hemodynamics being predominantly of hyperkinetic type. Treatment with cavinton, cavinton plus corglucone resulted in improvement of bloodflow in the affected major brain arteries at the expense of a compensating redistribution of bloodflow from intact collectors to the stenosed arteries basin. Changes in central hemodynamics were manifested by increase in the number of cases presenting with eukinetic-type circulation at the expense of decrease in those of hyperkinetic type. Under hypokinetic type hemodynamics, it is advisable that cavinton be prescribed in combination with cardiac glycosides.

[The pentoxifylline and corglycon treatment of patients with circulatory encephalopathy against a background of atherosclerotic lesions of the major cerebral arteries]. / Likuvannia pentoksyfilinom i korhlikonom khvorykh na dystsyrkuliatornu entsefalopatiiu na foni aterosklerotychnoho urazhennia mahistral'nykh arterii holovy.

As many as 34 patients having stage II-III atherosclerotic dyscirculatory encephalopathy with coexisting ischemic heart disease in the presence of stenosing and occlusive lesions of major brain arteries were evaluated for effects pentoxiphyllin and corglycon on the clinical course of this medical condition as well as systemic and cerebral haemodynamics. In this series, 82.7 percent of patients derived benefit from a single intravenous infusion of pentoxiphyllin and corglycon and course treatment with these drug preparation that was evidenced by an improvement in the parameters of systemic and cerebral hemodynamics and regression of neurologic symptomatology. The results of the studies made permit recommending pentoxiphyllin in combination with corglycon for treatment of those DE patients with eukinetic and hypokinetic types systemic haemodynamics, whereas pentoxiphyllin alone--for those with hyperkinetic type of haemodynamics, taking into consideration its cardiodepressive effects.