ABSTRACT
The aim of the study was to search for the association between efficacy of botulinum treatment (dysport) and the formation of antibodies to botulinum toxin in children with cerebral palsy (CP). Fourteen children with CP received dysport, 42 children (29 with CP and 13 patients with paresises of other etiologies) were not treated with this drug. No association between the presence of antibodies in blood serum and efficacy of treatment was found. However, further research of the role of antibody genesis as a factor influencing the formation of reaction to treatment is needed.
Subject(s)
Antibodies, Bacterial/blood , Botulinum Toxins, Type A/immunology , Botulinum Toxins, Type A/therapeutic use , Cerebral Palsy/drug therapy , Cerebral Palsy/immunology , Adolescent , Cerebral Palsy/blood , Child , Child, Preschool , Female , Humans , MaleABSTRACT
The findings of immunologic examinations of patients with sarcoidosis and sarcoids of the skin are reviewed. Immune disorders in these conditions are identical. Lowered cellular immunity activity and elevated humoral immunity activity have been revealed. Increased level of circulating immune complexes evidences the process activity in both sarcoidosis and sarcoids of the skin. The intensity of immune disorders does not depend on the disease duration, form, and dissemination.
Subject(s)
B-Lymphocytes/pathology , Sarcoidosis/pathology , Skin Diseases/pathology , T-Lymphocytes/pathology , Adult , B-Lymphocytes/immunology , Cell Differentiation , Chronic Disease , Female , Humans , Male , Middle Aged , Sarcoidosis/immunology , Skin/immunology , Skin/pathology , Skin Diseases/immunology , T-Lymphocytes/immunologyABSTRACT
The authors' findings confirm the possibility of such forms. In 16.5% of cases lupus erythematosus transforms from the discoid form and in 6.9% of cases from the disseminated form, immunologically presenting as T- or B-dependent lupus erythematosus. The authors describe immunocorrecting therapy for various forms of the disease, including immunosuppression of T- and B-lymphocytes by the quinoline series drugs or by their combinations with corticosteroids, as well as immunostimulation of T-lymphocytes by the imidazole series drugs or by thymus hormones.
