ABSTRACT
AIM: To study remodeling of heart and its influence on intracellular metabolism of neutrophils in obese men. MATERIALS AND METHODS: 85 men aged 30-63 years free from coronary heart disease underwent ECG examination with the evaluation of diastolic properties and diagnostics of left ventricle remodeling with special reference to oxygen-dependent metabolism and antioxidant protection of neutrophils. RESULTS AND DISCUSSION: Increased degree of obesity in men leads to enhanced frequency of diastolic dysfunction and left ventricular myocardium remodeling accompanied by a rise in myeloperoxidase activity in neutrophils. The latter was especially high in patients with concentric hypertrophy of left ventricular myocardium. CONCLUSION: Increased degree of heart remodeling with enhanced severity of obesity in men is accompanied by activation of oxygen-dependent metabolism in neutrophils.
Subject(s)
Neutrophils/metabolism , Obesity , Ventricular Dysfunction, Left , Ventricular Remodeling , Adult , Heart Failure, Diastolic/etiology , Heart Failure, Diastolic/metabolism , Heart Failure, Diastolic/physiopathology , Humans , Hypertrophy, Left Ventricular/etiology , Hypertrophy, Left Ventricular/metabolism , Hypertrophy, Left Ventricular/physiopathology , Male , Middle Aged , Obesity/complications , Obesity/metabolism , Obesity/physiopathology , Oxidative Stress , Severity of Illness Index , Statistics as Topic , Ventricular Dysfunction, Left/etiology , Ventricular Dysfunction, Left/metabolism , Ventricular Dysfunction, Left/physiopathologyABSTRACT
Treatment of rat hepatocyte plasma membranes with five novel synthetic heteroprostanoids of A- and E-types significantly decreased basal activity of adenylyl cyclase. Inhibition of forskolin-stimulated activity of the enzyme was seen as well. The maximal effective concentration for all substances tested was found at approximately 5x10(-6)-1x10(-5) M. The values of half maximal concentration (IC50) for all prostanoids were at the region of 0.7-1.1 microM. Prostanoids belonging to cyclopentenone group A (U-39, U-26) were less active than analogs of 11-deoxy-PGE1 (TA-227, TA-280, and TA-239). The strongest inhibitory effect of adenylyl cyclase activity (more than 3 times) was determined in the presence of prostanoid TA-227 possessing hydrophobic 15-phenyl ring and isoxazol group in omega-chain. The investigation of AC activity in the presence of different concentrations of prostanoids and varying concentrations of Mg x ATP has demonstrated that a non-comprehensive mechanism with particular effect takes place in case of AC inhibition by the heteroprostanoids.
Subject(s)
Adenylyl Cyclase Inhibitors , Enzyme Inhibitors/pharmacology , Hepatocytes/enzymology , Prostaglandins/chemistry , Adenylyl Cyclases/metabolism , Alprostadil/analogs & derivatives , Alprostadil/metabolism , Animals , Cell Membrane/metabolism , Colforsin/metabolism , Cyclic AMP/metabolism , Dose-Response Relationship, Drug , Hepatocytes/drug effects , Hepatocytes/metabolism , Inhibitory Concentration 50 , Male , Models, Chemical , Prostaglandins/metabolism , Rats , Rats, WistarABSTRACT
Discusses the methodological problems of forensic psychiatric evaluations of mental disorders in the structure of the most incident endogenous psychosis, schizophrenia, under conditions of expert evaluation in a civil process. Presents criteria permitting the differentiation between pathological states.
Subject(s)
Mental Competency/legislation & jurisprudence , Schizophrenic Psychology , Civil Rights/legislation & jurisprudence , Forensic Psychiatry/legislation & jurisprudence , Humans , Mental Competency/psychology , Psychopathology , RussiaSubject(s)
Crime , Social Behavior Disorders/diagnosis , Women , Female , Humans , Psychopathology , Social Behavior Disorders/psychology , Sociology , USSR , Women/psychologySubject(s)
Eyelids/injuries , Wounds, Nonpenetrating/surgery , Wounds, Penetrating/surgery , Adolescent , Adult , Aged , Child , Eyelids/surgery , Humans , Middle Aged , Surgery, Plastic/methodsSubject(s)
Alcoholism/therapy , Alcoholism/diagnosis , Alcoholism/psychology , Combined Modality Therapy/methods , Female , HumansSubject(s)
Eye Injuries/surgery , Eyelids/surgery , Surgery, Plastic , Adult , Eye Injuries/etiology , Eye, Artificial , Eyelids/injuries , Female , Humans , Male , Middle AgedSubject(s)
Eyelids/injuries , Military Medicine , Orbit/injuries , Surgical Flaps , Wounds, Gunshot/surgery , Aged , Follow-Up Studies , Humans , Male , Middle Aged , Time FactorsSubject(s)
Eyelids/injuries , Surgery, Plastic/methods , Wounds, Gunshot/surgery , Adult , Eyelids/surgery , Humans , Male , Middle Aged , Surgical FlapsSubject(s)
Eye Burns/surgery , Eye Injuries/surgery , Eyelids/surgery , Surgery, Plastic/methods , Adolescent , Adult , Eyelids/abnormalities , Eyelids/injuries , Female , Humans , Male , Wounds, Gunshot/complicationsSubject(s)
Dura Mater/transplantation , Eyelids/surgery , Skin Transplantation , Surgical Flaps , Adult , Embryo, Mammalian , Eyelids/injuries , Female , Humans , Male , Middle Aged , Pregnancy , Surgery, Plastic/methods , Transplantation, HomologousSubject(s)
Eyelids/surgery , Accidents, Traffic , Adolescent , Adult , Eyelids/injuries , Female , Humans , Male , Methods , Middle Aged , Skin Transplantation , Surgical Flaps , Transplantation, AutologousSubject(s)
Burns/surgery , Eyelids/surgery , Skin Transplantation , Eyelids/injuries , Humans , Transplantation, AutologousSubject(s)
Eye Diseases/surgery , Surgery, Plastic/methods , Adult , Follow-Up Studies , Humans , Middle AgedABSTRACT
Described and figured are deutonymphs of 18 species of the genus Hirstionyssus Fonseca, 1948, parasites of small mammals (H. carnifex (L. C. Koch) Oudemans, 1913; H. blanchardi (Trouessart, 1904); H. ellobii Bregetova, 1956; H. myospalacis Zemskaja et Piontkovskaja, 1957; H. transiliensis Bregetova, 1956; H. georgicus Bregetova, 1956; H. sciurinus (Hirst, 1921); H. confucianus (Hirst, 1921); H. bregetovae Razumova, 1953; H. macedonicus (Hirst, 1921); H. pauli Willmann, 1952; H. criceti (Sulzer, 1774); H. latiscutatus (Meillon et Lavoipierre, 1944); H. apodemi Zuevsky, 1970; H. pavlovskii Zemskaja, 1959; H. soricis (Turk, 1945); H. meridianus Zemskaja, 1955; H. isabellinus Oudemans, 1913); Keys to deutonymphs of the genus Hirstionyssus are given for the first time.
