[The importance of food and drug plant factors in the combined treatment of patients with type-II diabetes mellitus]. / Znachenie pishchevykh i lekarstvennykh rastitel'nykh faktorov v kompleksnom lechenii bol'nykh sakharnym diabetom II tipa.

A study was made of the effect of natural (vegetable dish) and refined (food methylcellulose--MC-100 and citrus pectin) vegetable fibers and Arfazetin (antidiabetic species, USSR) on the level of glucose, immunoreactive insulin (IRI), C-peptide, glucagon and gastrin in the blood of 41 patients with type II diabetes mellitus. These parameters were investigated on an empty stomach, 1, 2 and 4 h after breakfast I with a standard set of foodstuffs and minimum content of nutritive fibers. Similar investigations were conducted after intake of the same breakfast I in combination with various vegetable components. All the vegetable factors under study were shown to contribute to a decrease in a value of a glycemic rise noted after food intake. A vegetable dish and Arfazetin equally caused a significant rise of IRI secretion and C-peptide 60-90 min. after breakfast. MC-100 and particularly pectin decreased IRI and C-peptide secretion. There was a significant rise of gastrin secretion 1, 2 and 4 h when pectin was added to breakfast. When Arfazetin, a vegetable dish and MC-100 were added to breakfast I, a tendency to a rise of serum gastrin was observed 1 h after breakfast. The level of IRG during investigations with vegetable components did not differ from the results of investigations without these components.

[Arfazetin in the treatment of diabetes mellitus]. / Arfezetin v lechenii sakharnogo diabeta.

Hypoglycemic activity of arfazetin, a Soviet antidiabetic species of medicinal plants, was studied in 32 patients with diabetes mellitus, types I and II. Arfazetin was administered to patients with diabetes mellitus, type I, in combination with a diet and an adequate dose of insulin. All the patients with diabetes mellitus, type II, were given infusion in addition to a diet and hypoglycemic drugs. The conclusions were the following. The species possessed hypoglycemic activity. In patients with diabetes mellitus, type II, it made it possible to decrease or even give up a daily dose of hypoglycemic drugs per os. In patients with diabetes mellitus, type II, arfazetin produced no significant effect on the level of hypoglycemia. The optimum daily dose of arfazetin was 1 glass of infusion prepared ex tempore out of 5 g of dried species to be taken 30 min. before meal (one-third of glass) 3 times a day for one month.

[Effect of dietary supplements with different cellulose content on the blood glucose and insulin levels in type II diabetes mellitus]. / Vliianie pishchevykh nagruzok s razlichnym soderzhaniem kletchatki na uroven' gliukozy i insulina v krovi u bol'nykh sakharnym diabetom II tipa.

The influence of cellulose-containing vegetables, added to the breakfast, on the blood glucose and insulin levels, was investigated in patients, suffering from type II diabetes mellitus and healthy humans. It was shown, that cellulose promotes a decrease in the glycemia and a rise in the insulin level 1 to 1.5 hours after the breakfast. On the basis of their own results and data of other authors it was concluded that cellulose exerts a good effect upon the blood glucose level and its use should be recommended as a dietetic treatment component in patients with type II diabetes mellitus.

[Use of teronak for the treatment of obesity with and without diabetes mellitus]. / Primenenie preparata teronak v lechenii bol'nykh ozhireniem i pri sochetanii ozhireniia s sakharnym diabetom.

The anorectic drug teronak (made by "Sandoz") was used in the treatment of 73 obese patients, 34 of whom suffered from diabetes mellitus. The drug is well tolerated and had no side effects. Its positive action on the carbohydrate and lipid metabolism was noted during the treatment. The mean loss of weight after a 12-week treatment constituted 10.1 +/- 0.6 kg.

[Disorders of lipid content of blood in diabetes mellitus]. / O narusheniiakh soderzhaniia lipidov v krovi bol'nykh sakharnym diabetom.

The authors present the results of prospective study of the blood serum lipids (total cholesterol, triglycerides, lipoproteid fractions) in 132 patients with diabetes mellitus aged from 35 to 60 years and in 47 healthy persons of the same age (control group). The majority of the patients examined (60.6%) showed hyperlipidemia; types II and IV were most frequent. An increase in the content of the probeta-lipoproteid fraction and hypertriglyceridemia were mostly encountered in patients with macroangiopathies, particularly in the presence of adiposity. There was revealed no significant relationship between the frequency of hyperlipidemia and the severity of diabetes mellitus. However, the most distinct lipid disturbances were found in the patients with the disease of moderate severity. This was apparently connected with the prevalence in this group of persons with an excessive weight. As revealed, the incidence of hyperlipidemia rose on account of increased level of both total cholesterol and of triglycerides (with a tendency to their greater content in women).

[Excretion of aldosterone in the urine, renin activity in the plasma and some indices of the metabolism of potassium and sodium in patients with the iodiopathic edema syndrome]. / Ekskretsiia al'dosterona s mochoi, aktivnost' renina v plazme i nekotorye pokazateli obmena kaliia i natriia u bol'nykh s sindromom idiopaticheskikh otekov

It appeared that urinary aldosterone excretion was increased in 23 of 35 patients with a syndrome of idiopathic edema. The plasma renin activity failed to differ from the norm; consequently it can be supposed that the renin-angiotensin system played no significant role in the mechanism of hyperaldosteronism development in this form of pathology. A negative sodium balance was revealed in some of the patients with an edema syndrome and hyperaldosteronism.

[The nutrition of obese patients with diabetes mellitus]. / O pitanii bol'nykh s ozhireniem, stradaiushchikh sakharnym diabetom

The authors elaborated the main principles of diet therapy in diabetics with adipostiy: their weight was normalized with the aid of a low caloric diet with limited amount of carbohydrates and fats, but with the normal protein content. Two groups should be distinguished among the adipose patients: those without diabetic ketoaoidosis in the anamnesis or during the observation period; their diet differed by the extent of limiting of carbohydrates. As a result of the treatment carbohydrate metabolism was compensated with normalization of the glycemic curve; a tendency to normalization of lipid metabolism was noted; immunoreactive properties of the organism were increased.