ABSTRACT
The study was conducted in 3 Russian centers (Moscow, St. Petersburg and Nizhniy Novgorod). The total sample included 110 patients whose mental state met the definition of <
Subject(s)
Alzheimer Disease/prevention & control , Amino Acids/administration & dosage , Cognition Disorders/drug therapy , Neuroprotective Agents/administration & dosage , Vinca Alkaloids/administration & dosage , Administration, Oral , Aged , Aged, 80 and over , Alzheimer Disease/complications , Alzheimer Disease/physiopathology , Cognition/drug effects , Cognition Disorders/complications , Cognition Disorders/physiopathology , Dose-Response Relationship, Drug , Female , Follow-Up Studies , Humans , Infusions, Intravenous , Male , Middle Aged , Prospective Studies , Syndrome , Time Factors , Treatment OutcomeSubject(s)
Dementia, Vascular/drug therapy , Nootropic Agents/therapeutic use , Piracetam/therapeutic use , Dementia, Vascular/diagnosis , Dementia, Vascular/psychology , Female , Humans , Male , Middle Aged , Nootropic Agents/administration & dosage , Piracetam/administration & dosage , Psychiatric Status Rating Scales , Time Factors , Treatment OutcomeABSTRACT
Mild Cognitive Impairment (MCI) means cognitive deterioration not yet causing disability or dementia. Aged patients with MCI constitute a group of high risk for Alzheimer disease and other types of dementia. Currently, there is no generally adopted approach to MCI management but medications with neuroprotective properties are presumed to be the most perspective. Presented are the results of a multicentral open-label clinical trial of vascular and neuroprotective drug tanakan (EGb 761). The study has shown the decrease of cognitive impairment, which was both clinically and statistically significant, in patients at early stages of vascular and neurodegenerative pathological process. Probable efficacy of long-term tanakan treatment in prevention of dementia is discussed.
Subject(s)
Cognition Disorders/drug therapy , Plant Extracts/therapeutic use , Alzheimer Disease/epidemiology , Cognition Disorders/diagnosis , Cognition Disorders/epidemiology , Drug Administration Schedule , Female , Ginkgo biloba , Humans , Male , Middle Aged , Neuropsychological Tests , Severity of Illness IndexABSTRACT
Diffuse cerebral ischemia and circulatory hypoxia were modeled by carotid arteries occlusion in 40 white Wistar male rats. The changes of microcirculation bed and neurons of the sensomotor cortical area in hypoxia, preventive and therapeutic regimes of ceruloplasmin injections were compared to the neocortex state of intact rats. The changes of the neocortical ultrastructure established by electron microscopy were characteristic of hypoxic lesions described earlier in the literature. As a result of prolonged administration of ceruloplasmin there was a significant decrease of sensomotor neocortical hypostasis and improvement of microcirculation that suggested its neuroprotective properties.