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Otolaryngol Head Neck Surg ; 126(6): 683-9, 2002 Jun.
Article in English | MEDLINE | ID: mdl-12087338

ABSTRACT

OBJECTIVE: Cisplatin is a widely used, very effective chemotherapeutic agent that can cause severe ototoxicity. In this study, D-methionine was tested as an otoprotectant via round window membrane (RWM) application in the chinchilla. METHODS: A minute amount of cisplatin alone, or D-methionine followed by cisplatin, was applied topically directly to the intact RWM of anesthetized adult chinchillas. Auditory brainstem responses were measured before and 1 week after topical round window application. Animals were killed, and the cochleas were examined. RESULTS: The ears pretreated with D-methionine were completely protected from hearing loss and hair cell loss in the organ of Corti compared with controls. The ears receiving cisplatin without D-methionine protection sustained nearly complete hearing loss with threshold shifts of >60 dB, with extensive outer hair cell loss throughout the organ of Corti but particularly in the basal turn. CONCLUSION: These results demonstrate that topical D-methionine provides excellent otoprotection against cisplatin-induced ototoxicity both electrophysiologically and structurally.


Subject(s)
Cisplatin/adverse effects , Cochlea/pathology , Hearing Loss, Sensorineural/chemically induced , Hearing Loss, Sensorineural/prevention & control , Methionine/pharmacology , Round Window, Ear/drug effects , Administration, Topical , Animals , Audiometry , Auditory Threshold , Chinchilla , Cochlea/drug effects , Disease Models, Animal , Drug Interactions , Female , Male , Reference Values , Round Window, Ear/pathology , Sensitivity and Specificity
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