[Decreased humoral immunity to the tick-borne encephalitis virus in the population of the western Urals]. / Ponizhenie gumoral'nogo immuniteta k virusu kleshchevogo éntsefalita u naseleniia Zapadnogo Urala.

A serological survey of the human population in the western Urals in 1966-1968 and repeated survey in 1988-1989, the decrease in humoral immunity to tick-borne encephalitis virus in all age groups of people was established in most of landscape subzones of the region. The most expressive decrease of humoral immunity was noted in middle-aged people living in the subzone of broad-leaved and coniferous forests and forest steppe.

[Use of the specific rosette formation test in tick-borne encephalitis for the purpose of laboratory diagnosis]. / Ispol'zovanie testa spetsificheskogo rozetkoobrazovaniia pri kleshchevom éntsefalite s tsel'iu laboratornoi diagnostiki.

In the study of blood samples collected from patients with tick-borne encephalitis, the modified antigen-specific rosette formation test with erythrocytes, loaded with tick-borne encephalitis virus antigen via the specific immunoglobulin, has been used. The number of rosette-forming cells has been the highest during the acute period of the disease. The use of this test has confirmed the clinical diagnosis of the disease, together with hemagglutination inhibition serving as the main diagnostic test, in 35% of cases. The results of this study make it possible to recommend the antigen-specific rosette formation test for the early diagnosis of tick-borne encephalitis.