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1.
J Registry Manag ; 42(2): 40-7, 2015.
Article in English | MEDLINE | ID: mdl-26360105

ABSTRACT

BACKGROUND: In 2016, the cancer registry community will directly assign T, N and M components of stage. The Surveillance, Epidemiology, and End Results program implemented a field study to determine how often T, N and M were not available in the medical record, requiring the registrar to directly assign clinical or pathologic TNM stage components. The field study also identified specific training needs. METHODS: T, N and M status were collected from multiple sources within medical records for a total of 280 cases, 56 each from breast, prostate, colon, lung, and ovarian cancer. TNM data elements were also directly assigned by a series of reviewers and by study participants using the medical records with TNM information redacted. Availability of physician-assigned TNM was estimated from the medical record. Also, participant responses were compared to preferred answers. RESULTS: Pathologic T, N and M were available more often in the medical records than were clinical values and varied by site. Pathologic T and N were available for about two-thirds of the cases, but the clinical elements were available for only about 20% of cases. The agreement between participant responses and review panel assignments varied by data element and cancer site. Agreement was modest for most data elements and cancer sites, ranging from 54% for clinical T to 92% for clinical M for all cancer sites combined. CONCLUSIONS: The data elements for TNM staging and stage group were often missing from the medical records, so registrars in the field will need to assign TNM frequently. Furthermore, the results of this study strongly suggest that more training is required, even among those who currently assign TNM.


Subject(s)
Inservice Training/standards , Neoplasm Staging/standards , SEER Program/organization & administration , Humans , Medical Records/standards , Needs Assessment , SEER Program/standards
2.
Cancer ; 120 Suppl 23: 3807-14, 2014 Dec 01.
Article in English | MEDLINE | ID: mdl-25412392

ABSTRACT

BACKGROUND: The objectives of this article are to assess the completeness of the data collected on site-specific factors (SSFs) as a part of Collaborative Stage (CS) version 2 and the impact of the transition from the American Joint Committee on Cancer's (AJCC) 6th to 7th edition guidelines on stage distribution. METHODS: Incidence data for melanomas of the skin from 18 Surveillance, Epidemiology, and End Results (SEER) registries (SEER-18) were analyzed. Percentages of unknown cases for 7 SSFs were examined, along with staging trends from 2004 to 2010 and differences in AJCC 6th and 7th edition stage distributions for 2010 cases. RESULTS: Fewer than 10% of cases were coded as unknown for SSFs 1 (measured thickness), 2 (ulceration), and 3 (lymph node metastasis). For the remaining SSFs, 36-81% of cases were coded as unknown. Stage distributions were relatively consistent across time and between the AJCC 6th and 7th editions, with the exception of stage IA and stage INOS (not otherwise specified), for which a shift in cases was observed between the AJCC 6th and 7th edition guidelines fOR 2010 cases. CONCLUSIONS: A shift of cases out of stage IA and into stage INOS was observed between the AJCC 6th and 7th edition guidelines for 2010 cases. This was attributed to the high number of cases coded as unknown for SSF7 (primary tumor mitotic count/rate). The percentage of cases coded as unknown varied by SSF. Data completeness presents an issue for SSFs introduced in CS version 2.


Subject(s)
Choroid Neoplasms/pathology , Conjunctival Neoplasms/pathology , Head and Neck Neoplasms/pathology , Iris Neoplasms/pathology , Lymph Nodes/pathology , Melanoma/pathology , Registries , Skin Neoplasms/pathology , Cohort Studies , Eye Neoplasms/pathology , Humans , Neoplasm Staging/trends , Retrospective Studies , SEER Program
3.
J Am Acad Dermatol ; 65(5 Suppl 1): S69-77, 2011 Nov.
Article in English | MEDLINE | ID: mdl-22018070

ABSTRACT

BACKGROUND: An estimated 750,000 melanoma survivors in the United States are at increased risk of subsequent primary cancers. OBJECTIVE: We sought to assess the risk of developing subsequent primary cancers among people with cutaneous melanoma. METHODS: Using 1992 to 2006 data from the National Cancer Institute Surveillance, Epidemiology, and End Results Program, 40,881 people with in situ melanoma and 76,041 people with invasive melanoma were followed up (mean of 5.6 years) for the development of subsequent primary cancers. The observed number of subsequent cancers was compared with those expected based on age-/race-/year-/site-specific rates in the Surveillance, Epidemiology, and End Results population. Standardized incidence ratios (SIRs) (SIR = observed number/expected number) were considered statistically significant if they differed from 1, with an alpha level of 0.05. RESULTS: After a first primary in situ melanoma, risk was significantly elevated for subsequent invasive melanoma and chronic lymphocytic leukemia among men (SIRs = 8.43 and 1.44, respectively) and women (SIRs = 12.33 and 1.79, respectively). After a first primary invasive melanoma, risk was significantly elevated for subsequent invasive melanoma, thyroid cancer, non-Hodgkin lymphoma, and chronic lymphocytic leukemia among both men (SIRs = 12.50, 2.67, 1.56, and 1.57, respectively) and women (SIRs = 15.67, 1.77, 1.42, and 1.63, respectively). LIMITATIONS: Case ascertainment issues particularly affecting in situ melanoma cases could affect results. The role of detection bias in the diagnoses of some subsequent cancers cannot be completely eliminated. CONCLUSIONS: The findings of the study should guide the development of strategies such as posttreatment surveillance, screening, and ultraviolet exposure education among melanoma survivors to improve cancer survivorship.


Subject(s)
Melanoma/epidemiology , Neoplasms, Second Primary/epidemiology , Skin Neoplasms/epidemiology , Adolescent , Adult , Aged , Female , Humans , Leukemia, Lymphoid/epidemiology , Leukemia, Lymphoid/etiology , Lymphoma, Non-Hodgkin/epidemiology , Lymphoma, Non-Hodgkin/etiology , Male , Melanoma/etiology , Melanoma/pathology , Middle Aged , Neoplasm Invasiveness , Neoplasms, Second Primary/etiology , Neoplasms, Second Primary/pathology , Risk Factors , SEER Program , Sex Factors , Skin Neoplasms/etiology , Skin Neoplasms/pathology , Thyroid Neoplasms/epidemiology , Thyroid Neoplasms/etiology , United States/epidemiology , Young Adult
4.
Cancer ; 113(10 Suppl): 2919-25, 2008 Nov 15.
Article in English | MEDLINE | ID: mdl-18980275

ABSTRACT

BACKGROUND: The recent licensure of human papillomavirus (HPV) vaccines will likely decrease the development of primary in situ and invasive cervical cancers and possibly other HPV-associated cancers such as vaginal, vulvar, and anal cancers. Because the HPV vaccine has the ability to impact the development of >1 HPV-associated cancer in the same individual, the risk of developing subsequent primary cancers among cervical cancer survivors was examined. METHODS: Using the 1992 through 2004 data from the Surveillance, Epidemiology, and End Results (SEER) program, 23,509 cervical cancer survivors were followed (mean of 4.8 person-years) for the development of subsequent primary cancers. The observed number (O) of subsequent cancers of all sites were compared with those expected (E) based on age-/race-/year-/site-specific rates in the SEER population. Standardized incidence ratios (SIRs = O/E) were considered statistically significant if they differed from 1, with an alpha level of 0.05. RESULTS: Among cervical cancer index cases, there was a significant elevated risk for subsequent in situ cancers of the vagina and vulva (SIRs of 53.8 and 6.6, respectively); and invasive vaginal, vulvar, and rectal cancers (SIRs of 29.9, 5.7, and 2.2, respectively). Significantly elevated risks were observed across race and ethnic populations for subsequent vaginal in situ (SIR for whites of 49.4; blacks, 52.8; Asian/Pacific Islander [API], 91.4; and Hispanics, 55.7) and invasive cancers (SIR for whites of 25.7; blacks, 34.5; API, 48.5; and Hispanics, 25.2). CONCLUSIONS: The results of the current study demonstrate a substantially increased risk of the development of subsequent primary in situ and invasive cancers among cervical cancer survivors and have implications for the development of prevention and early detection strategies as the role of HPV infection becomes evident.


Subject(s)
Carcinoma in Situ/epidemiology , Carcinoma in Situ/virology , Neoplasms, Second Primary/epidemiology , Neoplasms, Second Primary/virology , Papillomavirus Infections/complications , Uterine Cervical Neoplasms/epidemiology , Adolescent , Adult , Age Factors , Aged , Aged, 80 and over , Anus Neoplasms/epidemiology , Carcinoma in Situ/complications , Child , Female , Humans , Middle Aged , Papillomavirus Infections/epidemiology , Racial Groups , Risk , SEER Program , Survivors , United States/epidemiology , United States/ethnology , Uterine Cervical Neoplasms/ethnology , Vaginal Neoplasms/epidemiology , Vaginal Neoplasms/virology , Vulvar Neoplasms/epidemiology , Vulvar Neoplasms/virology
5.
Cancer ; 113(5 Suppl): 1256-65, 2008 Sep 01.
Article in English | MEDLINE | ID: mdl-18720381

ABSTRACT

BACKGROUND: Previous studies identified disparities in incidence rates of cancers of the oral cavity and pharynx between American Indians/Alaska Natives (AI/AN) and non-Hispanic whites (NHW) and differences between various AI/AN populations. Reporting among AI/AN has been hampered by: 1) heterogeneity among various anatomic sites of oral cavity and pharyngeal cancers obscuring unique patterns of individual anatomic sites; 2) race misclassification and underreporting of AI/AN; and 3) sparseness of data needed to identify regional variations. METHODS: To improve race classification of AI/AN, data from US central cancer registries were linked with Indian Health Service (IHS) records. AI/AN incidence data from 1999 to 2004 were stratified by sex, age, stage at diagnosis, and anatomic subsite for 6 IHS geographic regions and compared with NHW populations. RESULTS: For all oral cavity and pharynx cancers combined, among residents of Contract Health Service Delivery Area counties, AI/AN overall had significantly lower incidence rates than NHW (8.5 vs 11.0). However, AI/AN rates were significantly higher in the Northern Plains (13.9 vs 10.5) and Alaska (16.3 vs 10.6), significantly lower in the Pacific Coast (7.7 vs 11.6) and Southwest (3.3 vs 10.4), and similar in the Southern Plains (11.4). Overall AI/AN males had higher incidence rates than AI/AN women. Nasopharyngeal cancer was more frequent (1.1AI/AN vs 0.4 NHW), and tongue cancer less frequent (1.6 AI/AN vs 2.9 NHW) in AI/AN than NHW populations; however, rates varied by region. Stage distribution was modestly less favorable for AI/AN compared with NHW populations. CONCLUSIONS: Variation by region, anatomic site, and sex indicates a need for research into etiologic factors and attention to regional risk factor profiles when planning cancer control programs.


Subject(s)
Indians, North American/statistics & numerical data , Inuit/statistics & numerical data , Mouth Neoplasms/ethnology , Pharyngeal Neoplasms/ethnology , Aged , Alaska/epidemiology , Female , Humans , Incidence , Middle Aged , Population Surveillance , Racial Groups/statistics & numerical data , Registries , United States/epidemiology
6.
Cancer ; 107(5 Suppl): 1162-71, 2006 Sep 01.
Article in English | MEDLINE | ID: mdl-16838312

ABSTRACT

BACKGROUND: Studies of persons with colorectal cancer have reported increased risk of subsequent primary cancers. Results have not been consistent, however, and there is little information about such risk in specific races and ethnic populations. METHODS: Using 1975-2001 data from the Surveillance, Epidemiology, and End Results (SEER) Program, we assembled 262,600 index cases of colorectal carcinoma to assess the occurrence of subsequent primary cancers in 13 noncolonic sites. Observed (O) subsequent cancers were compared with those expected (E) based on age-/sex-/race-/year-/site-specific rates in the SEER population. The standardized incidence ratio (SIR) and the absolute excess risk (AER) represent 'O / E' and 'O - E,' respectively. RESULTS: Colorectal carcinoma patients had significantly elevated SIRs for small gut, stomach (males), kidney, and corpus uteri cancers, ranging from 1.13 for stomach cancer in males to 3.45 for small gut cancer in females. Elevated SIRs for additional sites were seen in certain population subgroups: pancreas and ovary in persons aged <50 years, and prostate in black males. The excess burden, as assessed by AER, was notable for prostate cancer in black males and for corpus uteri cancer in females aged <50 years (26.5 and 9.5 cancers per 10,000 person-years, respectively), and it persisted beyond 5 years of follow-up. CONCLUSIONS: Although significantly elevated SIRs were found for several cancers, the excess burden was notable only for cancer of the prostate in black males and of the corpus uteri in females under age 50.


Subject(s)
Colorectal Neoplasms/epidemiology , Neoplasms, Second Primary/epidemiology , Aged , Female , Follow-Up Studies , Humans , Incidence , Male , Middle Aged , Prostatic Neoplasms/epidemiology , Risk , SEER Program , Survivors , United States/epidemiology , Uterine Neoplasms/epidemiology
7.
Gynecol Oncol ; 86(2): 190-1, 2002 Aug.
Article in English | MEDLINE | ID: mdl-12144827

ABSTRACT

OBJECTIVE: The objective of this study was to evaluate treatment and survival for women with fallopian tube carcinoma in a population-based data set. METHODS: Using the National Cancer Institute's Surveillance, Epidemiology, and End Results program, we identified 416 women with fallopian tube carcinoma diagnosed between 1990 and 1997. We analyzed treatment and 5-year relative survival. We also compared survival to that of 9032 women with epithelial ovarian cancer diagnosed between 1991 and 1997. RESULTS: Almost half of those diagnosed with stage I/II disease did not undergo surgical evaluation of lymph nodes. Most women with stage I/II disease were treated with surgery alone, while most women with stage III/IV disease were treated with surgery and chemotherapy. Five-year relative survival by FIGO stage was as follows: stage I (N = 102), 95%; stage II (N = 29), 75%; stage III (N = 52), 69%; stage IV (N = 151), 45%. CONCLUSIONS: We observed better survival, stage by stage, for women with fallopian tube carcinoma than for women with epithelial ovarian cancer in this population-based data set. It is possible that some patients with advanced, bulky carcinoma arising in the fallopian tube may have been classified as having ovarian or primary peritoneal cancer. Women with fallopian tube cancer should be treated in accordance with the same guidelines for surgical staging, debulking, and adjuvant chemotherapy as for women with epithelial ovarian cancer. Further studies, both laboratory and clinical, are needed to delineate the differences between fallopian and ovarian cancers.


Subject(s)
Carcinoma/mortality , Carcinoma/therapy , Fallopian Tubes , Genital Neoplasms, Female/mortality , Genital Neoplasms, Female/therapy , Adult , Aged , Carcinoma/drug therapy , Carcinoma/surgery , Chemotherapy, Adjuvant , Female , Genital Neoplasms, Female/drug therapy , Genital Neoplasms, Female/pathology , Genital Neoplasms, Female/surgery , Humans , Middle Aged , Neoplasm Staging , Ovarian Neoplasms/mortality , Ovarian Neoplasms/therapy , SEER Program , Survival Analysis , Treatment Outcome , United States/epidemiology
8.
Gynecol Oncol ; 86(1): 34-7, 2002 Jul.
Article in English | MEDLINE | ID: mdl-12079297

ABSTRACT

OBJECTIVES: The objectives of this study were to ascertain long-term survival and patterns of care among women diagnosed with ovarian tumors of low malignant potential (LMP) in a population-based data set. METHODS: Using the NCI's Surveillance, Epidemiology, and End Results (SEER) database, we identified 2818 women diagnosed with ovarian tumors of low malignant potential between 1988 and 1997. RESULTS: By FIGO stage, 10-year relative survival was as follows: stage I, 99%; stage II, 98%; stage III, 96%; and stage IV 77%. One-quarter of women with stage I disease underwent partial or unilateral oophorectomy only, while women with more advanced disease commonly underwent omentectomy, unilateral or bilateral oophorectomy, and hysterectomy. Adjuvant chemotherapy was given to about 30% of women with stage III and IV disease. Radiation therapy was rarely used. We observed no significant changes in primary surgery or adjuvant treatment over time. CONCLUSIONS: The diagnosis of an ovarian tumor of LMP conveys a relatively benign prognosis. Conservative surgery should be considered in younger women with early-stage disease. There are insufficient data to support a role for adjuvant chemotherapy for women with advanced disease.


Subject(s)
Ovarian Neoplasms/mortality , Ovarian Neoplasms/therapy , Adult , Chemotherapy, Adjuvant , Female , Humans , Hysterectomy , Neoplasm Staging , Ovarian Neoplasms/pathology , Ovariectomy , Radiotherapy, Adjuvant , Survival Rate
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