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1.
Nutrients ; 12(10)2020 Sep 28.
Article in English | MEDLINE | ID: mdl-32998324

ABSTRACT

Improvements in macular pigment optical density (MPOD) and contrast sensitivity after administration of 12 mg lutein alone and the timing at which efficacy is observed remain unknown. Therefore, lutein (12 mg), a crystalline formulation, was used in this study, considering its bioaccessibility. This study aimed to determine the effects of lutein administration for 16 weeks on MPOD, contrast sensitivity, and glare sensitivity, and changes in serum lutein levels were determined. The study subjects comprised 59 healthy male and female adults aged 20-69 years. The study diet included a placebo (placebo group) or a diet supplemented with 12 mg of lutein (lutein group). Each study diet was continuously administered for 16 weeks. At weeks 8 and 16, MPOD, contrast sensitivity, glare sensitivity, and serum lutein levels were evaluated. Compared with the placebo group, the lutein group showed significantly improved MPOD, contrast sensitivity, and glare sensitivity at week 16 and significantly increased serum lutein levels at weeks 8 and 16. Continuous administration of lutein for 16 weeks, considering its bioaccessibility, increased MPOD; it made the outlines of visible objects clearer and was effective in inhibiting decreases in visual function caused by glare from light.


Subject(s)
Contrast Sensitivity/drug effects , Dietary Supplements , Lutein/blood , Lutein/pharmacokinetics , Macular Pigment/metabolism , Adult , Aged , Biological Availability , Double-Blind Method , Female , Glare , Healthy Volunteers , Humans , Macular Degeneration/prevention & control , Male , Middle Aged , Visual Acuity , Young Adult
2.
Nutrients ; 12(3)2020 Feb 25.
Article in English | MEDLINE | ID: mdl-32106548

ABSTRACT

A 12-week-long randomized, double-blind, placebo-controlled, parallel-group comparison trial was conducted to determine the effects of long-term standardized bilberry extract (SBE) intake on tonic accommodation of ciliary muscle caused by visual display terminal (VDT) tasks. This study was compliant with the accordance with CONSORT 2010 statement. A total of 109 healthy adult men and women aged 20-60 years were recruited and randomized into SBE and placebo groups. The subjects in the SBE and placebo groups were administered 240 mg of SBE and placebo, respectively, once daily for 12 weeks. Tests were performed before and after VDT tasks at week 0, 4, 8, and 12; high-frequency component (HFC)-1 value was the evaluation outcome. Results showed that post-load HFC-1 values at weeks 8 and 12 were significantly improved in the SBE group than in the placebo group (p = 0.014 and 0.017, respectively). Regarding the difference between before and after the task load (ΔHFC-1), the values were significantly better in the SBE group than in the placebo group at week 4 and 12 (p = 0.018 and 0.049, respectively). This study shows that oral consumption of 240 mg SBE extract for 12 weeks relieves the tonic accommodation of the ciliary muscle caused by VDT tasks and near-vision tasks.


Subject(s)
Accommodation, Ocular/drug effects , Anthocyanins/administration & dosage , Eye/drug effects , Muscle Contraction/drug effects , Muscle, Smooth/drug effects , Accommodation, Ocular/physiology , Administration, Oral , Adult , Double-Blind Method , Drug Administration Schedule , Female , Healthy Volunteers , Humans , Male , Middle Aged , Muscle, Smooth/physiology , Plant Extracts , Treatment Outcome , Vaccinium myrtillus , Young Adult
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