ABSTRACT
Onenewalkaloid; (+)-N-(2-hydroxypropyl)lindcarpine (1),together with four known aporphine alkaloids, (+)-boldine (2) (+)-norboldine (3), (+)-lindcarpine (4) and (+)-methyllindcarpine (5) were isolated from the stem bark of Actinodaphne pruinosa Nees (Lauraceae). (+)-N-(2-Hydroxypropyl)lindcarpine (1) exhibited cytotoxic activity against P-388 murine leukemia cells with an IC(50 )value of 3.9 microg/mL. Structural elucidation of all the compounds were performed by spectral methods such as 1D- and 2D- NMR, IR, UV, and HRESIMS.
Subject(s)
Aporphines/chemistry , Cytotoxins/chemistry , Lauraceae/chemistry , Animals , Aporphines/isolation & purification , Aporphines/pharmacology , Cell Line, Tumor , Cell Survival/drug effects , Cytotoxins/isolation & purification , Cytotoxins/pharmacology , Magnetic Resonance Spectroscopy , Mass Spectrometry , Mice , Molecular Structure , Plant Stems/chemistry , Spectrophotometry, UltravioletABSTRACT
A novel polyisoprenyl benzophenone derivative named eugeniaphenone (1) was isolated from the stem bark of Garcinia eugeniaefolia Wall. Its structure was elucidated by spectroscopic methods, including 1D and 2D NMR techniques, and confirmed by single-crystal X-ray diffraction analysis. It is the first example in which an isoprenyl unit formed a cyclobutane-containing side chain in the polyisoprenyl benzophenone derivatives.
Subject(s)
Benzophenones/isolation & purification , Garcinia/chemistry , Hemiterpenes/isolation & purification , Benzophenones/chemistry , Hemiterpenes/chemistry , Molecular Conformation , Plant Bark/chemistryABSTRACT
A new xanthone, yahyaxanthone (1), was isolated from Garcinia rigida leaves. Cytotoxicity evaluation showed that 1 was inhibitory to L1210 cell, with an IC50 value 4.08 microg/ml.
Subject(s)
Antineoplastic Agents, Phytogenic/pharmacology , Garcinia , Phytotherapy , Plant Extracts/pharmacology , Animals , Antineoplastic Agents, Phytogenic/administration & dosage , Antineoplastic Agents, Phytogenic/chemistry , Antineoplastic Agents, Phytogenic/therapeutic use , Cell Line, Tumor/drug effects , Inhibitory Concentration 50 , Magnetic Resonance Spectroscopy , Mice , Plant Extracts/administration & dosage , Plant Extracts/chemistry , Plant Extracts/therapeutic use , Plant Leaves , Xanthones/administration & dosage , Xanthones/chemistry , Xanthones/pharmacology , Xanthones/therapeutic useABSTRACT
From the stem bark of Garcinia benthami a new benzophenone, named Salimbenzophenone, was isolated. The structure was determined by means of spectroscopic analysis.
Subject(s)
Benzophenones/chemistry , Garcinia/chemistry , Plant Bark/chemistry , Benzophenones/isolation & purification , Indonesia , Molecular Structure , Spectroscopy, Fourier Transform InfraredABSTRACT
Two new xanthons, musaxanthone (1) and asmaxanthone (2) were isolated from the leaves of Garciniarigida. The structures were determined by means of spectroscopic analysis.
