Subject(s)
Laryngeal Neoplasms/pathology , Lymph Nodes/cytology , Adult , Aged , Cell Adhesion , Cytotoxicity, Immunologic , Humans , Laryngeal Neoplasms/immunology , Male , Middle AgedSubject(s)
Neck , Tuberculosis, Lymph Node , Adolescent , Adult , Child , Child, Preschool , Diagnosis, Differential , Female , Humans , Male , Middle Aged , Recurrence , Tuberculosis, Lymph Node/diagnosis , Tuberculosis, Lymph Node/drug therapySubject(s)
Carcinoma, Squamous Cell/immunology , Laryngeal Neoplasms/immunology , T-Lymphocytes/immunology , Adolescent , Adult , Aged , Antibodies, Neoplasm/biosynthesis , Carcinoma, Squamous Cell/pathology , Humans , Hyperplasia , Laryngeal Neoplasms/pathology , Lymph Nodes/pathology , Lymphocyte Activation , Middle Aged , PhagocytosisABSTRACT
In 40 patients with carcinoma of the larynx transformation of lymphocytes under the influence of PHA was studied. In 20 patients, in addition, venous blood flowing from the tumor, collected during the operation was also examined. In 33 patients the index of blastic transformation was lowered as compared with that in the control group. In 15 of 20 patients, the lymphocytes of venous blood from the vicinity of the tumor showed significantly higher indices of blastic transformation in comparision with those from peripheral blood. It was assumed that difference was due to an increased participation of T-lymphocytes in venous blood flowing from the tumor area. T-lymphocytes might move into the blood from the lymphoid infiltrates which accompany the neoplastic tissue.
Subject(s)
Laryngeal Neoplasms/immunology , Lymphocyte Activation , Adolescent , Adult , Aged , Female , Humans , Male , Middle AgedABSTRACT
In the search of microscopic manifestations of cellular defense in tumor disease, larynx specimens removed surgically for carcinoma of the larynx and neighboring lymph nodes were studied morphologically. Blastic transformation of lymphocytes from the lymph nodes was also investigated. Activity of nuclear chromatin of these cells was assessed on the basis of its sensitivity to acid hydrolysis in the reaction of Feulgen and incorporation of labeled 3H-actinomycin D. The results indicate existence of cellular defense reaction in carcinoma of the larynx, around the primary tumor as well as in neighboring lymph nodes. Intensity of the reaction in lymph nodes increases with growth of the primary tumor.
