[Effects of trivalent antimony on the rat hormonal status under experimental conditions].

The paper gives the data of experimental studies of oral trivalent antimony used at 1 and 20 maximum permissible concentrations (MPC) on the rat hormonal status. The findings are indicative of the specific features of changes in the hormonal status of experimental animals depending on the dose of trivalent antimony. The concentration of trivalent antimony at the level of 20 MPC is shown to act as a role of a reprotoxic agent that causes a change in the serum content of hormones, such as follicle-stimulating and luteinizing ones.

[Some environmental and hygienic aspects of preschool children's health in an industrial town]. / Nekotorye ékologo-gigienicheskie aspekty zdorov'ia doshkol'nikov promyshlennogo goroda.

The results of a medical genetic study of the spread of congenital morphogenetic types (CMGT) among 3-7-year-old children living in Magnitogorsk whose territory is highly polluted with chemical compounds are presented. In Magnitogorsk, the mean of CMGT cases per child is 2.89, which is much greater than the respective values for environmentally favorable cities and towns in Russia. The most common signs are as follows: diastema (137.79 cases per 1000 children), clinodactyly (135.98 per 1000), epicanthus (122.44 per 1000), and wide umbilical ring (110.71 per 1000).

[Parent's occupation as an important factor effecting health status of children (review)]. / Professiia roditelei - vazhnyi faktor vliianiia na zdorové detei (obzor).

Review of literature demonstrated that adverse occupational exposures of the parents caused prezygotic and transplacental changes in both parents and their children. Embryotoxic and teratogenic effects in children of workers engaged in some types of production are described. Analysis of the contribution of parental profession to risk of oncologic diseases in children represents a new trend of studies. Hypotheses on teratogenic and carcinogenic mechanisms of the said changes are offered.

[Comparative analysis of oncological morbidity in the population of an industrial city and workers of a metallurgical plant]. / Sravnitel'nyi analiz onkologicheskoi zabolevaemosti naseleniia promyshlennogo goroda i rabotnikov metallurgicheskogo kombinata.

Analytical epidemiology techniques were used to study the malignant neoplasms prevalence in the population of Magnitogorsk (400,000), and among the workers engaged in the Magnitogorsk metallurgical plant (64,000 workers). Revealed was that the malignant neoplasms related morbidity rate was 1.6 higher in men and 3.2 higher in women among the plant workers as compared with the city population in general. The cancer risk factors were predominantly occupational ones, e. i. the major industrial carcinogens--benzopyrene in tars and carbon-black; benzol, chromium and nickel in the dust; the carcinogenesis modifying substances--nitrogen oxide, sulfur dioxide, phenols, iron oxides, lead and its non-organic compounds, high temperatures. The data received can be used in further studies and elaboration of primary preventive measures.

[Malignant neoplasms of the stomach in metallurgy workers]. / O zlokachestvenykh novoobrazovaniiakh zheludka u rabochikh metallurgicheskoi promyshlennosti.

The results of long-term studies of factors of gastric carcinogenesis in steel workers are presented. Relationships between tumor incidence and effects of iron dust, oil aerosols containing heavy hydrocarbons, high temperature and nitrogenous gases were established. Chronic gastric diseases aggravated by highly-hazardous industrial environmental factors increase the risk of carcinogenesis. Measures aimed at preventing primary gastric tumor development in steel workers should include dust and oil aerosol control and timely identification and treatment of chronic gastric lesions.