ABSTRACT
Prajmaline is not a relatively well known and frequently used antiarrhythmic belonging to Class IA group of antiarrhythmics, which was administered to a young male with metoprolol for the treatment of parasystole. The patient took in 120 mgs prajmaline and 600 mgs metoprolol during the day of the case, which leads to cardiogenic shock, ventricular tachycardia and ventricular fibrillation. The patient's parameters were normalized after successful resuscitation, temporary pacemaker and two days long Dopamin therapy. Therapy was not regarded to be necessary for a few ventricular premature beats detected during a week observation period. The patient is without complaints now, and significant ventricular arrhythmias, or malignant ventricular ectopy hasn't been proved with ECG tests and Holter monitoring for more than three months. Due to adverse effect profile of prajmaline, even at commonly used doses it should be administered carefully and other agents should probably be considered first before beginning long term treatment with prajmaline.
Subject(s)
Anti-Arrhythmia Agents/poisoning , Metoprolol/poisoning , Prajmaline/poisoning , Shock, Cardiogenic/chemically induced , Adult , Anti-Arrhythmia Agents/administration & dosage , Anti-Arrhythmia Agents/pharmacokinetics , Dose-Response Relationship, Drug , Drug Overdose , Drug Synergism , Humans , Male , Metoprolol/administration & dosage , Metoprolol/pharmacokinetics , Prajmaline/administration & dosage , Prajmaline/pharmacokinetics , Ventricular Fibrillation/chemically inducedSubject(s)
Porphyrias/diagnosis , Abdomen, Acute/diagnosis , Acute Disease , Adult , Colic/diagnosis , Diagnosis, Differential , Female , Humans , Male , Porphyrins/urineABSTRACT
In 29 cases of chronic renal failure 1325 peritoneal dialyses were performed between January 1, 1976 and April 31, 1978. The technique of peritoneal dialysis, the general lines of supervision and follow-up, the results and shortcomings of the procedure are discussed. Peritoneal dialysis is regarded as an alternative to haemodialysis in chronic renal failure. On ground of the favourable observations, organization of satellite PD services on a large scale, parallel with the expansion of other services (haemodialysis, renal transplantation), is advocated.