ABSTRACT
BACKGROUND: Optic pathway glioma (OPG) is a characteristic hallmark of neurofibromatosis type I (NF-I). OBJECTIVE: To evaluate the feasibility of magnetic resonance diffusion tensor imaging (MRDTI) at 3T to detect abnormalities of the optic nerves and optic radiations in children with NF-I. MATERIALS AND METHODS: 3-T MRDTI was prospectively performed in 9 children with NF-I (7 boys, 2 girls, average age 7.8 years, range 3-17 years) and 44 controls (25 boys, 19 girls, average age 8.1 years, range 3-17 years). Fractional anisotropy (FA) and mean diffusivity were determined by region-of-interest analysis for the optic nerves and radiations. Statistical analysis compared controls to NF-I patients. RESULTS: Two NF-I patients had bilateral optic nerve gliomas, three had chiasmatic gliomas and four had unidentified neurofibromatosis objects (UNOs) along the optic nerve pathways. All NF-I patients had statistically significant decreases in FA and elevations in mean diffusivity in the optic nerves and radiations compared to age-matched controls. CONCLUSION: MRDTI can evaluate the optic pathways in children with NF-I. Statistically significant abnormalities were detected in the diffusion tensor metrics of the optic nerves and radiations in children with NF-I compared to age-matched controls.
Subject(s)
Diffusion Tensor Imaging/methods , Neurofibromatosis 1/pathology , Optic Nerve Glioma/pathology , Optic Nerve/pathology , Adolescent , Anisotropy , Case-Control Studies , Child , Child, Preschool , Feasibility Studies , Female , Humans , Image Interpretation, Computer-Assisted , Male , Prospective Studies , Reproducibility of ResultsABSTRACT
PURPOSE: To establish normative magnetic resonance diffusion tensor imaging (MRDTI) data in the pediatric optic nerve and compare to pathologic conditions both intrinsic and extrinsic to the anterior optic nerve pathway. MATERIALS AND METHODS: A retrospective analysis of MRDTI at 3.0T in children ages 0-18 with both normal imaging studies and with pathologic conditions either arising from the optic nerves or exerting mass effect on the anterior optic pathways was performed. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values were obtained within the posterior part of the intraorbital optic nerves. Statistical analysis compared normal controls to optic pathway lesions. RESULTS: Lesions intrinsic to the optic nerve including septo-optic dysplasia and optic nerve glioma demonstrated statistically significant reductions in FA and increases in ADC values. There was no statistically significant difference in FA or mean diffusivity between the normal controls and patients with lesions extrinsic to the optic nerve but exerting mass effect on the visual pathway. CONCLUSION: MRDTI is a feasible technique for evaluating the optic nerves in pediatric patients. It may play a role in presurgical planning by demonstrating integrity of the visual pathway in patients with resectable lesions, allowing for minimization of morbidity associated with vision loss.
Subject(s)
Diffusion Magnetic Resonance Imaging/methods , Optic Nerve Diseases/pathology , Optic Nerve/pathology , Adolescent , Analysis of Variance , Anisotropy , Child , Child, Preschool , Humans , Infant , Infant, Newborn , Optic Nerve/anatomy & histology , Reference Values , Retrospective StudiesABSTRACT
BACKGROUND: Septo-optic dysplasia (SOD) refers to a heterogeneous group of midline brain developmental anomalies, with optic nerve hypoplasia (ONH) being one of the morphologic correlates of the condition. Traditionally, ONH has been diagnosed on fundoscopic exam. Conventional MRI is used in cases of suspected ONH to identify associated brain abnormalities and to compare findings to the fundoscopic exam. Advances in magnetic resonance diffusion tensor imaging (MRDTI) permit in vivo, noninvasive, quantitative characterization of the entire visual pathway at 3.0 T. OBJECTIVE: To investigate the feasibility of MRDTI at 3.0 T in children with SOD to evaluate the entire visual pathway. MATERIALS AND METHODS: MRDTI at 3T was performed in two children with SOD and seven age-matched controls. Manual region-of-interest analysis was used to evaluate the tensor metrics of the optic nerves. Deterministic tractography was used to evaluate the tensor metrics of the optic radiations. RESULTS: The SOD patients demonstrated a significant decrease in anisotropy and increase in mean diffusivity of the optic nerves and radiations compared to the control subjects. CONCLUSION: This study demonstrates the feasibility of MRDTI to evaluate the entire visual pathway in children, and it demonstrates pre- and post-chiasmatic diffusion tensor abnormalities in SOD patients.
