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J Neuroimmunol ; 142(1-2): 93-100, 2003 Sep.
Article in English | MEDLINE | ID: mdl-14512168

ABSTRACT

Anti-Hu syndrome is a paraneoplastic neurologic disease seemingly associated with an efficient antitumoral immune response against HuD protein expressed by both small cell lung cancer (SCLC) and neurons. Since anti-Hu antibodies are not pathogenic, and oligoclonal CD8(+) T cells infiltrate neoplastic and nervous tissues, we examined MHC class I-restricted immunogenicity of human HuD. Among 14 HuD-derived peptides potentially immunogenic in HLA-A*0201 restriction, 10 had actual in vitro binding capacity to the HLA molecule, 8 elicited specific cytotoxic T lymphocytes (CTLs) in a humanized murine model after peptidic vaccination, 2 also elicited specific CTLs in healthy humans, and 1 was naturally processed and presented to the immune system.


Subject(s)
Antigens, Neoplasm/immunology , Cytotoxicity, Immunologic/immunology , Nerve Tissue Proteins/immunology , Paraneoplastic Syndromes, Nervous System/immunology , Peptide Fragments/immunology , RNA-Binding Proteins/immunology , Animals , Antigen Presentation , Antigens, Neoplasm/administration & dosage , Antigens, Neoplasm/metabolism , Cell Line, Tumor , ELAV Proteins , ELAV-Like Protein 4 , HLA-A Antigens/immunology , HLA-A Antigens/metabolism , HLA-A2 Antigen , Humans , Injections, Intramuscular , Mice , Mice, Knockout , Mice, Transgenic , Nerve Tissue Proteins/administration & dosage , Nerve Tissue Proteins/metabolism , Paraneoplastic Syndromes, Nervous System/genetics , Peptide Fragments/administration & dosage , Peptide Fragments/metabolism , Protein Binding/immunology , RNA-Binding Proteins/administration & dosage , RNA-Binding Proteins/metabolism , T-Lymphocytes, Cytotoxic/immunology , T-Lymphocytes, Cytotoxic/metabolism , Vaccines, Subunit/administration & dosage , Vaccines, Subunit/immunology
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