ABSTRACT
BACKGROUND: The purpose of the study was to determine the intensity of control over negative emotions of anger, depressed mood, and anxiety in certain skin diseases such as psoriasis and vitiligo, and to define the predictors of this emotional control in terms of the illness perception in the following context: duration of illness, age at onset, subjective knowledge of the causes of illness, subjective sense of control over the disease. METHODS: The study included 60 patients with psoriasis (n = 30) and vitiligo (n = 30) as well as healthy persons (n = 60) matched to the experimental group in terms of gender, age, and level of education. Control of negative emotions was examined by means of Watson and Greer's Courtauld Emotional Control Scale (Polish adaptation by Juczynski) and the illness perception by means of Kossakowska's Chronic Patients Questionnaire. RESULTS: The research concludes that psoriasis patients control negative emotions more intensively than healthy people. Vitiligo patients on the other hand do not differ in the control of negative emotions compared with healthy subjects. There are no significant predictors of negative emotional control in vitiligo. In psoriasis gender and age are the main contributors to negative emotional control and anger control is predicted by the age at onset as well. CONCLUSION: The specificity of the skin disease affects maladaptive negative emotional control and the suggestion is to use psychological treatment in hospitalised psoriasis in particular.
Subject(s)
Adaptation, Psychological , Affective Symptoms/psychology , Psoriasis/psychology , Sick Role , Vitiligo/psychology , Adult , Affective Symptoms/complications , Affective Symptoms/therapy , Anger , Anxiety/psychology , Databases, Factual , Depression/psychology , Female , Humans , Male , Middle Aged , Predictive Value of Tests , Psoriasis/complications , Psoriasis/therapy , Psychotherapy , Regression Analysis , Self Efficacy , Surveys and Questionnaires , Vitiligo/complications , Vitiligo/therapy , Young AdultABSTRACT
The authors investigated the immunological and pharmacological activity of N-/2, 4-dimethylacetanilido/iminodiacetic complex compounds with calcium and zinc (HEPIDA-Ca and HEPIDA-Zn). An antiinflammatory, therapeutic effect of these compounds and also an immunosuppressive action were observed. Both complex compounds inhibited the GvH reaction in rats and attenuated the transplantation barrier.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Arthritis/drug therapy , Calcium/therapeutic use , Edema/drug therapy , Graft vs Host Reaction/drug effects , Imino Acids/pharmacology , Imino Acids/therapeutic use , Organometallic Compounds/pharmacology , Zinc/therapeutic use , Animals , Anti-Inflammatory Agents, Non-Steroidal/pharmacology , Female , Imino Acids/metabolism , Organometallic Compounds/metabolism , Rats , Rats, Inbred StrainsSubject(s)
Antigen-Antibody Complex/analysis , Myocarditis/immunology , Adult , Female , Humans , Male , Myocarditis/etiologyABSTRACT
The study concerns the effect of cysteine derivatives and its hydrazides on cell mediated immunity. Cysteine derivatives appeared to exert marked suppressive influence on development and course of post-adjuvant polyarthritis in rats. L-cysteine hydrazides prolonged skin allograft survival time in rats to higher degree than cysteine. The results of in vitro experiments point to the inhibition of the non-stimulated and stimulated PHA incorporation of 3H-thymidine by lymphocytes. It was observed that cysteine derivatives examined, and mainly its hydrazides, exert stronger than cysteine suppressive effect on cell mediated immune response.
Subject(s)
Cysteine/analogs & derivatives , Immunity, Cellular/drug effects , Animals , Arthritis/immunology , Cysteine/pharmacology , Female , Graft vs Host Reaction/drug effects , Immunosuppression Therapy , Lymphocyte Activation/drug effects , Male , Rats , Skin Tests , Structure-Activity RelationshipABSTRACT
The authors investigated the immunological and pharmacological activity of l-cysteine hydrazide. It was found, that the preparation exhibited an interesting immunosuppressive and anti-inflammatory effect, which was evoked by the interference of the drug in nucleic acids and by stabilization of the cell membranes. Moreover it diminished the number of T lymphocytes. L-cysteine hydrazide showed no significant side effects. The authors discussed the possibility of its application in clinical therapy.
Subject(s)
Cysteine/analogs & derivatives , Immunosuppressive Agents , Analgesia , Animals , Anti-Inflammatory Agents, Non-Steroidal , Arthritis, Experimental/drug therapy , Cysteine/immunology , Cysteine/toxicity , Dogs , Guinea Pigs , Hemodynamics/drug effects , Immunity, Cellular/drug effects , Immunosuppressive Agents/pharmacology , Immunosuppressive Agents/toxicity , Mice , Muscle, Smooth/drug effects , Rabbits , Rats , Respiration/drug effectsABSTRACT
The immunosuppressive action of N,N, S-trimethyl-cysteine, S-methyl-L-cysteine hydrazide hydrochloride and L-cysteine hydrazide on the course of post-adjuvant polyarthritis, graft-versus-host reaction, turpentine oedema and incorporation of 3H-thymidine into spontaneous or PHA stimulated lymphocyte cultures was examined. Inhibition of post-adjuvant polyarthritis and prolongation of skin allograft survival time were observed. L-cysteine hydrazide had shown the most inhibiting action. In vitro, S-methyl-L-cysteine hydrazide hydrochloride decreased and N,N, S-trimethyl-cysteine increased the incorporation of 3H-thymidine into the lymphocyte cultures stimulated by PHA. The obtained results were compared with the action of DL-cysteine hydrochloride.
