[Free-radical reactions in Daphnia after low doses of γ-irradiation in vivo].

A violation of free-radical reactions has been found by the method of free-radical copolymerization in the two groups of Daphnia magna exposed to 100 and 1000 mGy of gamma-rays and their non-exposed first generation progeny. The method is based on a quantitative radiometric registration of the polymerization process that develops in the cells of a multicellular organism in tissue in proportion to the existing number of free radicals. The fact of the increased level of free radicals may be indicative of the hereditary transgenerational effect and the cause of lower survival of Daphnia in both generations. However, the effect of a reduced survival rate does not persist in the second generation, which can be explained by the effect of radiation on the embryos of the first generation after acute irradiation of parents.

[Neuropeptide thyroliberin in ultra low doses--anticonvulsant defense of the brain]. / Neiropeptid tiroliberin--protivosudorozhnaia zashchita mozga v sverkhmalykh dozakh.

Thyroliberin (TRH) promoting endogeneous antidepressive effect is the most general regulator of the central mechanisms and visceral functions (especially respiration). Our group pioneered in applying the anticonvulsant action of TRH after local intranasal application). This application of TRH in ultra-low doses contrast the method of systemic TRH administration in the large doses). In our experiments intranasal application of 10(-8), 10(-10) and 10(-12) mol/l TRH significantly inhibited the severe epileptic motor fits in rats induced by PTZ. EEG also confirms beneficent effect of TRH (TRH suppressed SWD in cortex, amygdala and hippocamp). In the experiment that follows compared effects of TRH (pyroGlu-His-Pro-NH2) and its metabolite dipeptide His-Pro (10(-10), 10(-8) mol/l). The experiments make more precise that only TRH but not His-Pro posses the anticonvulsant properties. There is a good believe that medical potentialities of TRH have not been exhausted and its new possibilities of its usage will be revealed in epileptology.

[The possibility of using the preparation MIGI-K in districts exposed to radioactive contamination following the accident at the Chernobyl AES]. / O vozmozhnosti ispol'zovaniia preparata MIGI-K v raionakh, podvergshikhsia radioaktivnomu zagriazneniiu posle avarii na Chernobyl'skoi AES.

A preparation from mussels, MIGI-K, used as an additive to the diet of people working at the Chernobyl power plant has proved to be efficient in increasing the total resistance of the body, including the resistance to ionizing radiation. In experiments with animals, MIGI-K has been shown to accelerate excretion of 45Ca and 86Rb from the body. The combination of these properties of MIGI-K permits us to consider it an efficient drug to be used within the regions affected by the Chernobyl disaster.

[The radiobiological characteristics of the P+ variant of Bacillus brevis var. G.--B. in relation to gramicidin S synthesis]. / Radiobiologicheskie osobennosti P+-varianta Bacillus brevis var. G.--B.v sviazi s sintezom gramitsidina S.

The radiosensitivity of P(+) variant Bacillus brevis var. G.-B. cells cultured under condition of normal and inhibited gramicidin S synthesis, antibiotically high-active strain and high radioresistant cells has been studied. It has been shown that the radioresistance of bacterial cells correlates, in general, with their antibiotic activity: the antibiotic superproduced is more radioresistant than P(+) variant, the inhibition of antibiotic synthesis by beta-phenil-beta-alanin rises a little the sensitivity of P(+) variant cells. But the radioresistant fraction of P(+) variant contains the lower antibiotic amount than the whole population. It has been concluded that the radioprotective action of gramicidin S can not be the only reason of the above-mentioned differences in radiosensitivity.