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Delayed Laboratory Response to COVID-19 Caused by Molecular Diagnostic Contamination.

Mögling, Ramona; Meijer, Adam; Berginc, Natasa; Bruisten, Sylvia; Charrel, Remi; Coutard, Bruno; Eckerle, Isabella; Enouf, Vincent; Hungnes, Olav; Korukluoglu, Gülay; Kossyvakis, Thanos; Mentis, Andreas; Molenkamp, Richard; Muradrasoli, Shaman; Papa, Anna; Pigny, Fiona; Thirion, Laurence; van der Werf, Sylvie; Reusken, Chantal.

Emerg Infect Dis ; 26(8): 1944-1946, 2020 08.

Article in English | MEDLINE | ID: mdl-32433015

ABSTRACT

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) created an exceptional situation in which numerous laboratories in Europe simultaneously implemented SARS-CoV-2 diagnostics. These laboratories reported in February 2020 that commercial primer and probe batches for SARS-CoV-2 detection were contaminated with synthetic control material, causing delays of regional testing roll-out in various countries.

Subject(s)

Artifacts , Betacoronavirus/genetics , Clinical Laboratory Techniques/standards , Coronavirus Infections/diagnosis , Coronavirus Infections/epidemiology , Pneumonia, Viral/diagnosis , Pneumonia, Viral/epidemiology , Reagent Kits, Diagnostic/standards , Reverse Transcriptase Polymerase Chain Reaction/standards , Betacoronavirus/pathogenicity , COVID-19 , COVID-19 Testing , Clinical Laboratory Techniques/methods , Coronavirus Envelope Proteins , Coronavirus Infections/virology , DNA Primers/analysis , DNA Primers/chemical synthesis , DNA Probes/analysis , DNA Probes/chemical synthesis , Delayed Diagnosis , Diagnostic Tests, Routine , Europe/epidemiology , Humans , Laboratories/organization & administration , Laboratories/standards , Pandemics , Pathology, Molecular , Pneumonia, Viral/virology , RNA-Dependent RNA Polymerase/genetics , Reagent Kits, Diagnostic/supply & distribution , Reverse Transcriptase Polymerase Chain Reaction/statistics & numerical data , SARS-CoV-2 , Viral Envelope Proteins/genetics

ABSTRACT

Subject(s)

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