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pH-dependent ileocolonic drug delivery, part II: preclinical evaluation of novel drugs and novel excipients.
Broesder, Annemarie; Kosta, Anne-Marijke M A C; Woerdenbag, Herman J; Nguyen, Duong N; Frijlink, Henderik W; Hinrichs, Wouter L J.
Drug Discov Today ; 25(8): 1374-1388, 2020 08.
Article in English | MEDLINE | ID: mdl-32562842

ABSTRACT

Novel drugs and novel excipients in pH-dependent ileocolonic drug delivery systems have to be tested in animals. Which animal species are suitable and what in vivo methods are used to verify ileocolonic drug delivery?


Subject(s)
Colon/metabolism , Drug Delivery Systems , Drug Evaluation, Preclinical , Excipients/administration & dosage , Ileum/metabolism , Pharmaceutical Preparations/administration & dosage , Animals , Humans , Hydrogen-Ion Concentration
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