ABSTRACT
Stimulation of alpha-adrenoceptors was simulated by intraarterial injection of 0.6 mmol CaCl2 in acute experiments on resting muscles of the dog hind leg. It has been demonstrated that alpha-adrenergic stimulation of metabolism in skeletal muscles has a vasodilative effect in the muscle-supplying vessels. It has been also shown that imitation of alpha-adrenergic stimulation effect by intraarterial injection of CaCl2 causes Ca- and alpha-adrenergic-dependent vasodilative reactions. It is suggested that disturbance of vasodilative effects caused by alpha-adrenergic stimulation in the effector tissues, counteracting the direct constrictive alpha-adrenoceptor effect in the smooth muscle cells of the vessel wall, can lead to systemic impairment of the vascular tone.
