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Ter Arkh ; 85(1): 69-75, 2013.
Article in Russian | MEDLINE | ID: mdl-23536950

ABSTRACT

AIM: To evaluate the efficiency of using a succinate-containing dialysis solution (SCDS) in terminal renal failure patients treated with chronic hemodialysis (CHD). SUBJECTS AND METHODS: Ninety patients from two hemodialysis units took part in the crossover study and were allocated to 2 groups. For 6 months, study group patients received CHD using SCDS and control group patients had CHD with a standard bicarbonate dialysis solution after 3-month washout period followed by decussation. The time course of changes in blood biochemical parameters, 24-hour ECG monitoring data, and quality of life indicators were estimated in the patients. RESULTS: After using acidosuccinate during hemodialysis, there was a significant reduction in the predialysis serum level of inorganic phosphate, a calcium phosphate product, gamma-glutamyl transpeptidase, urea, and aldosterone as compared to the control group. The blood concentration of total protein was also increased. After 6-month administration of acidosuccinate, the patients showed reductions in systolic blood pressure, heart rate, and the frequency and duration of ST-segment depression episodes. There were positive changes in the quality of life of patients according to the KDQOL-SF questionnaire. CONCLUSION: The use of SCDS in patients with CHD causes positive changes in a number of laboratory parameters and improves the physical and general status, and quality of life of patients.


Subject(s)
Acetates/pharmacology , Biomarkers/blood , Dialysis Solutions/pharmacology , Glomerular Filtration Rate , Kidney Failure, Chronic/therapy , Renal Dialysis/methods , Succinic Acid/pharmacology , Cross-Over Studies , Female , Follow-Up Studies , Humans , Kidney Failure, Chronic/blood , Kidney Failure, Chronic/physiopathology , Male , Middle Aged , Prospective Studies , Quality of Life , Treatment Outcome
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