ABSTRACT
Improvement of elderly cancer patients' treatment is an acute issue in oncology. The results of stage III rectal and colon cancer complex treatment are far from being satisfactory in this category of patients. In this connection the search for new adjuvant drugs supplementing radio and chemotherapy is urgent. The article describes pioneer experience in complex radical treatment of elderly cancer patients with immunomodulator Vilon included into the scheme of treatment. The obtained preliminary results of investigation suggest recommendation of Vilon application to increase 2-year survival of patients, prevention of post-operative complications, remote complications, recurrences and tumor dissemination, as well as the improvement of the quality of life after employment of aggressive methods of treatment.
Subject(s)
Colorectal Neoplasms/drug therapy , Colorectal Neoplasms/mortality , Dipeptides/therapeutic use , Immunologic Factors/therapeutic use , Adult , Aged , Colorectal Neoplasms/surgery , Combined Modality Therapy , Female , Humans , Middle Aged , Treatment OutcomeABSTRACT
Sex hormones (testosterone, estradiol) and thyroxine would activate irregularly the production of the specific group antigen (GS-antigen) of avian ribodesoxyviruses in the culture of "normal" chick embryonal cells (CEC, phenotype C/O, GS-). The mentioned hormones as well as hydrocortisone and insulin would not prevent the Rous sarcoma virus (RSV) infecting of CEC, render no essential action on the accumulation of RSV in the infected CEC culture, and failed to activate the formation of mature RSV in virogenic cultures of rat (XC, R--B77) and mice cells (DBA--B77).
Subject(s)
Hormones/pharmacology , Retroviridae/drug effects , Animals , Antigens, Viral , Avian Sarcoma Viruses/drug effects , Cells, Cultured , Chick Embryo , Epitopes , Estradiol/pharmacology , Genes, Viral/drug effects , Hydrocortisone/pharmacology , Mice , Rats , Testosterone/pharmacology , Thyroxine/pharmacology , Virus Cultivation , Virus Replication/drug effectsABSTRACT
The intracellular concentration of cyclic AMP in normal cells and in cells infected with the Rous sarcoma virus (chicken fibroblasts) was determined by the method of saturation analysis (method of concurrent binding with protein). Thyroxine (2 mcg/ml) increased the level of cyclic AMP both in normal and infected cells, insulin (2 mcg/ml) decreased the concentration of cyclic AMP in infected cells, but cholesterol (5 mcg/ml) exerted no effect on this parameter in infected cells. The data are discussed from the point of view of a possible influence of hormones on the cholesterol accumulation in cells and on the adenylatecyclase activity in cell membranes.
