1.
Bull Exp Biol Med
; 130(11): 1113-5, 2000 Nov.
Article
in English
| MEDLINE
| ID: mdl-11182831
ABSTRACT
High antiarrhythmic activity of a new Russian antiarrhythmic drug quaternidine in ventricular arrhythmia was studied in 96 coronary patients by Holter monitoring, bicycle ergometry, and echocardiography. The drug had a positive impact on local kinetics in left-ventricular ischemic myocardium and some parameters of bicycle exercise test. The preparation possesses no arrhythmogenic effect. Experiments on 30 random-bred rats showed that the drug reduced the necrotic zone under conditions of experimental coronary occlusion. Experiments on 14 intact cats demonstrated that quaternidine had no effect on coronary bloodflow.