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Lik Sprava ; (8): 84-9, 2006 Dec.
Article in Ukrainian | MEDLINE | ID: mdl-17427432

ABSTRACT

The authors carried out the sudy on morphofunctional changes of mitochondria of neurocytes of the brainstem of rats under experimental model of hypoxia and administration of Cerebrokurin and lipin. Cerebrokurin administration to rats which underwent severe chronic hypoxia lead to increase in mitochondria diameter and considerable increase of their area in the unit of volume as well it resulted in renewal of myelin sheaths. Use of Cerebrokurin and lipin in animals which underwent moderate hypoxia lead to probable increase in mitochondria area in the unit of volume in comparison with animals not treated with these agents.


Subject(s)
Amino Acids/therapeutic use , Brain , Fetal Hypoxia/pathology , Mitochondria/drug effects , Peptides/therapeutic use , Amino Acids/administration & dosage , Animals , Animals, Newborn , Brain/drug effects , Brain/metabolism , Brain/ultrastructure , Complex Mixtures , Disease Models, Animal , Drug Therapy, Combination , Energy Metabolism/drug effects , Female , Microscopy, Electron, Transmission , Mitochondria/metabolism , Mitochondria/ultrastructure , Mitochondrial Size/drug effects , Organic Chemicals/administration & dosage , Organic Chemicals/therapeutic use , Peptides/administration & dosage , Pregnancy , Rats
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