Current Concepts in the Surgical Management of Non-melanoma Skin Cancers.

The surgical management of non-melanoma skin cancers has seen some significant changes over the past 20 years, as a result of developments in three equally important and overlapping specialties that deal with this specific pathology: plastic and reconstructive surgery, surgical oncology and dermatological surgery. Better understanding of vascular and particularly microvascular anatomy, coupled with technological advances in operating microscopes, microsurgical instrumentation and preoperative planning via advanced imaging, allows functional and aesthetic restoration of any radical oncological skin and soft-tissue surgery defect from head to toe. As reconstruction has practically lost its technical boundaries, resectional surgery can be executed without compromising on surgical margins, thus reducing rates of local recurrences and metastatic spread. The increasing use of Mohs surgery and its several advantages for difficult high-risk non-melanoma skin cancer in facial sites especially, offers optimal cure rates while reducing functional impairment and optimising cosmetic outcomes. Advances in preoperative planning utilising computed tomography and magnetic resonance imaging scans can help to predict the degree of resectability and tailor further treatments, including radiotherapy, accordingly. From the reconstructive point of view, these techniques provide a roadmap to select the best blood supply for the transplanted flap, thereby reducing complications and increasing success rates. The focus of skin cancer surgery has therefore shifted from pure cancer clearance and flap survival, to a high degree of functional and aesthetic reconstruction.

Reconstruction of critically-sized perineal defect with perforator flap puzzle technique: a case report.

Extensive defects in perineal reconstruction cannot be effectively reconstructed with only a single perforator flap or other conventional techniques. We present a combination of three different types of flaps including pedicled ALT-rectus-vastus lateralis, gracilis-PAP flap and two IGAP flaps as an alternative option for reconstructing a critically-sized perineal defect.

Rare case of a liposarcoma in the brachial plexus.

Introduction A liposarcoma is a rare cancer of connective tissues that resemble fat cells under light microscopy. Case History A 73-year old female patient presented to our tertiary cancer centre with an eight-year history of a large, slow-growing painless mass in the right axilla. Magnetic resonance imaging showed a lipomatous, well-circumscribed mass of dimension 30 × 16 × 10cm extending towards the right clavicle and causing deformation to the right chest wall and right breast. Surgery revealed a large tumour that had stretched all three cords of the brachial plexus. Histopathology was consistent with a diagnosis of a low-grade liposarcoma. After a period of neuropraxia, the patient returned to normal activities 4 months after surgery. Conclusions Although extremely rare, low-grade liposarcomas of the brachial plexus should be considered in the differential diagnosis of a slow-growing axillary mass. Referral to a tertiary sarcoma centre is essential for an appropriate diagnosis, adequate treatment, and long-term follow-up.

The use of a failed flap as a biological dressing.

A patient with a narrowly excised squamous cell carcinoma on the scalp underwent a wider excision that involved burring of the underlying calvarium. The defect was reconstructed with a superficial temporal artery pedicled flap, which unfortunately failed. The patient had multiple co-morbidities, limiting reconstructive options. The failed flap was therefore maintained as a 'biological dressing' for several weeks. During this time, the patient was reviewed regularly in the dressing clinic and did not develop a wound infection. Six weeks later, he was taken back to theatre and the flap was debrided under local anaesthesia. Beneath the flap, there was sufficient healthy granulation tissue over the site of previous bony debridement to permit split skin grafting. We advocate this technique as a useful method for managing difficult wounds in complex patients with multiple co-morbidities where other reconstructive techniques are limited.

Determination of a CR-39 detector response to neutrons from an Am-Be source.

A comparison of experimental and calculated responses of a CR-39 detector to neutron spectra from an Am-Be source is presented. Code named Neutron_CR-39.F90 has been used to calculate the neutron dose equivalent as well as the track density. Conversion coefficient (sensitivity), between track density in track/cm(2) and neutron dose equivalent in mSv, was calculated and good agreement with experimental data was found. Sensitivity increases linearly with removed layer in the range between 6 µm and 24 µm.

Comparison of different methods for shielding design in computed tomography.

The purpose of this work is to compare different methods for shielding calculation in computed tomography (CT). The BIR-IPEM (British Institute of Radiology and Institute of Physics in Engineering in Medicine) and NCRP (National Council on Radiation Protection) method were used for shielding thickness calculation. Scattered dose levels and calculated barrier thickness were also compared with those obtained by scatter dose measurements in the vicinity of a dedicated CT unit. Minimal requirement for protective barriers based on BIR-IPEM method ranged between 1.1 and 1.4 mm of lead demonstrating underestimation of up to 20 % and overestimation of up to 30 % when compared with thicknesses based on measured dose levels. For NCRP method, calculated thicknesses were 33 % higher (27-42 %). BIR-IPEM methodology-based results were comparable with values based on scattered dose measurements, while results obtained using NCRP methodology demonstrated an overestimation of the minimal required barrier thickness.

Mammography practice in Serbia: evaluation and optimisation of image quality and the technical aspects of the mammographic imaging chain.

The purpose of this work was to assess mammography practice in Serbia and its appropriateness for both diagnostic service and potential screening by implementing quality control (QC) protocol in three large teaching hospitals. Corrective actions were suggested, accordingly. In addition to technical aspects of QC, image quality was assessed using image grading before and after the introduction of corrective measures. The survey demonstrated considerable variations in technical parameters that affect image quality and patients doses. Average glandular doses ranged from 1.8 to 2.8 mGy, while reference optical density (OD) ranged from 1.0 to 2.6. Image grading resulted in a very high percentage of images with poor quality (12-70 % for cranio-caudal projection and 8-66 % for medio-lateral oblique projection). Main problems were associated with film processing, viewing conditions and OD control. Following introduction of corrective measures, the image grading results were improved in some hospitals, so the percentage of images without any remarks has been increased.

Preoperative antiseptics in clean/contaminated maxillofacial and oral surgery: prospective randomized study.

In order to show the effectiveness of preoperative antiseptic mouthwash the authors undertook a prospective study in 120 patients who underwent elective surgery under general or local anesthesia. Patients were allocated toone of 4 groups, depending on whether the oral cavity was washed preoperatively with 1% cetrimide, chlorhexidine, povidon-iodine or sterilized normal saline solution (control group). Aerobic and anaerobic bacterial samples were taken from the inferior vestibulum mucosa before surgery, 5 min after the start of the operation and at the end of the procedure. The results show a statistically significant reduction in bacterial counts during procedures in which antiseptics are used to wash the oral cavity preoperatively. 1% cetrimide solution was the most successful in reducing intra-oral bacterial counts and produced the longest lasting antiseptic effect. Chlorhexidine is a good option for procedures longer than 1 hour, while povidon-iodine is recommended for procedures lasting up to 1 hour. Normal saline reduced bacterial counts in the specimen taken 5 min after washing but this short-lasting effect is due to mechanical cleansing rather than the antiseptic effect.

Anatomical aspects of the arterial blood supply to the sinoatrial and atrioventricular nodes of the human heart.

Classic anatomical dissection of 150 hearts from adults aged 18 - 80 years was performed. The sinoatrial (SA) node artery was most frequently a large atrial branch of the right coronary artery (63%), arising at a mean distance of 1.2 cm (range 0.2 - 2.2 cm) from its beginning, with a mean external diameter of 1.7 mm (range 1 - 3 mm). In 37% of cases the SA node artery was a branch of the left coronary artery or one of its branches, with an initial mean external diameter of 2.2 mm (range 2 - 3 mm). The origin of the SA node artery was not related to coronary arterial dominance. The atrioventricular (AV) node artery was the first and longest inferior septal perforating branch of the right (90%) or left (10%) coronary artery, arising from the U- or V-shaped segment of the corresponding artery at the level of the crux cordis. Mean external diameter was 2 mm (range 1 - 3.5 mm). The origin of the AV node artery was dependent on coronary arterial dominance. Identification of the anatomical variants of the arterial blood supply to the SA and AV nodes may help in overcoming potential difficulties in treating arrhythmias and in mitral valve surgery.

Anatomical variations of the coronary sinus ostium area of the human heart.

Classic anatomical dissection of 150 heart specimens from adults aged 18 - 80 years was performed. The Thebesian valve was absent in 20% of cases and, in these, 4% had a large ostial valve of the middle cardiac vein in front of the coronary sinus ostium. Fibres of Chiari were found in 10% of cases. Ostia of the middle cardiac vein, posterior veins of the left ventricle, small cardiac vein and deep cardiac veins were present in the distal 10 mm of the coronary sinus. Some samples had ostial and/or parietal valves or antivalves that sometimes contained muscular fibres. Distal accessory parietal valves (2%) and antivalves (1%) of the coronary sinus wall were found at a distance of 4 - 7 mm from its ostium. The frequency and variability of anatomical structures in the area of the coronary sinus ostium probably influence the haemodynamics of this area. Knowledge of and being able to identify these anatomical variations may help in identifying and overcoming potential difficulties in treating arrythmias and in cardiosurgery.

[Radiation burden of patients in conventional diagnostic radiology: analysis of radiologic practice in Serbia].

X-rays are by far most significant contributor to total population dose from man-made sources of radiation. Diagnostic reference levels provide frameworks to reduce variability. The aim of this study is to establish, for the first time, a baseline for national diagnostic reference levels in Serbia for the most common X-ray examination types. Dose estimates are based on measurements of kerma-area product and Entrance surface air kerma for at least ten patients for each examination type, in each of 16 randomly selected hospitals in Serbia. Mean, median and third quartile values of patient doses are reported. Results have shown wide variation of mean hospital doses. Entrance surface doses were compared with previously published diagnostic reference levels. Doses for all studied examination types except chest radiography were within European DRL. The reasons for dose variation are discussed. The findings emphasize the importance of regular patient dose measurement to ensure that patient doses are kept as low as reasonable achievable.