ABSTRACT
Functional magnetic resonance imaging can be used to study numerous brain dysfunctions, including disorders of the self, in substance-dependent individuals. The self as the sum of human concepts about oneself is regulated by the brain system close to the default mode network: the medial prefrontal cortex, posterior cingulated gyrus, and some parietal regions. However, the composition and activity of this system in mental disease, specifically, in substance addiction, are virtually not described. Our study showed that self-appraisal task in addicts activates the superior frontal cortex, cuneus, precuneus, angular gyrus, and posterior cingulated cortex. The involvement of the parietal (postcentral and supramarginal gyri) and temporal (superior temporal and Heschl's gyri) sensory areas is diminished. Hence, published data on the involvement of the cingulate cortex and prefrontal cortex in functional regulation of the self are confirmed. Activation-deactivation patterns in the parietal and temporal regions differ significantly from the previous descriptions.
