Subject(s)
Neoplasms/epidemiology , Adult , Age Factors , Aged , Female , Humans , Male , Middle Aged , Neoplasms/mortality , Poland , Registries/standards , Sex Factors , Time FactorsSubject(s)
Neoplasms/epidemiology , Female , Humans , Male , Neoplasms/mortality , Poland , Sex FactorsSubject(s)
Melanoma/mortality , Skin Neoplasms/mortality , Female , Follow-Up Studies , Humans , Male , Melanoma/therapy , Sex Factors , Skin Neoplasms/therapy , Time FactorsABSTRACT
A multicentric randomized trial evaluated the interest of internal mammary dissection on operable breast cancer patients. One thousand four hundred and fifty-three patients were included in the study and were followed for ten years. There is no difference in survival or in relapse-free survival between the two groups. There were significantly more local recurrences in the group without internal mammary dissection, but these recurrences occurred mainly on patients who developed metastases. A great difference between centers was observed in the number of nodes examined and there is therefore a difference in the prognostic value of the number of nodes invaded.
Subject(s)
Breast Neoplasms/surgery , Lymph Node Excision , Mastectomy/methods , Clinical Trials as Topic , Female , Humans , Middle Aged , Random AllocationSubject(s)
Sarcoma/pathology , Soft Tissue Neoplasms/pathology , Adolescent , Adult , Breast Neoplasms/pathology , Breast Neoplasms/secondary , Extremities , Female , Humans , Male , Middle Aged , Sarcoma/diagnosis , Sarcoma/surgery , Soft Tissue Neoplasms/diagnosis , Soft Tissue Neoplasms/surgery , Wounds and Injuries/complicationsSubject(s)
Breast Neoplasms/surgery , Evaluation Studies as Topic , Female , Humans , Mastectomy/methods , PrognosisSubject(s)
Breast Neoplasms/epidemiology , Adolescent , Adult , Aged , Female , Humans , Middle Aged , Poland , Rural Population , Urban PopulationABSTRACT
From 1963 to 1968, the international group collected 1580 cases of breast cancer, randomized into two therapeutic groups: radical mastectomy and extended mastectomy. The data were processed on the UNIVAC 1107 computer of the I.N.S.E.R.M. Computing Center. No significant difference was observed between the two groups in the overall five-year survival rate. However, a more detailed analysis, according to certain prognostic features, showed that extended mastectomy improved the results in one subgroup: cancers of inner or medial quadrants, axillary N+. Within this group the difference was highly significant for a smaller subgroup (190 patients) including only tumors T1 and T2. In conclusion, there is no indication for extended mastectomy in any cancers of the outer quadrants or in those of the inner or medial quadrants without axillary involvement. A limited indication for extended mastectomy may be provisionally retained for T1 and T2 cancers of the inner or medial quadrants with axillary involvement.