1.
Chem Pharm Bull (Tokyo)
; 48(12): 1978-85, 2000 Dec.
Article
in English
| MEDLINE
| ID: mdl-11145154
ABSTRACT
New fibrates containing piperidine, 4-hydroxypiperidine, piperidin-3-ene, and piperazine moieties in the structures were synthesized and evaluated. Among the synthesized compounds, 2-[3-[1-(4-fluorobenzoyl)-piperidin-4yl]phenoxyl-2-methylpropanoic acid (9aA: AHL-157) showed very superior activities in decreasing triglyceride, cholesterol, and blood sugar compared to bezafibrate in mice and rats.