1.
Ann Thorac Surg
; 78(4): 1453-5, 2004 Oct.
Article
in English
| MEDLINE
| ID: mdl-15464517
ABSTRACT
Systemic infection with Aspergillus fumigatus is an opportunistic disease that affects mainly immunocompromised hosts and is associated with a high mortality rate. We report a case of A. fumigatus endocarditis after an episode of thrombotic thrombocytopenic purpura. Diagnosis was established after sudden rupture of posterior papillary muscle of the normal native mitral valve. Soon after mitral valve replacement, Aspergillus endocarditis recurred, associated with multiple peripheral emboli, which necessitated a second operation.
Subject(s)
Amphotericin B/therapeutic use , Aspergillosis/microbiology , Aspergillus fumigatus/isolation & purification , Endocarditis/microbiology , Mitral Valve Insufficiency/etiology , Opportunistic Infections/microbiology , Purpura, Thrombotic Thrombocytopenic/complications , Amphotericin B/pharmacology , Anti-Infective Agents/therapeutic use , Aspergillosis/complications , Aspergillosis/drug therapy , Aspergillosis/surgery , Aspergillus fumigatus/drug effects , Candidiasis/complications , Candidiasis/drug therapy , Drug Resistance, Fungal , Embolism/etiology , Endocarditis/complications , Endocarditis/diagnostic imaging , Endocarditis/drug therapy , Endocarditis/surgery , Fatal Outcome , Female , Heart Valve Prosthesis Implantation , Humans , Immunocompromised Host , Immunosuppressive Agents/adverse effects , Immunosuppressive Agents/therapeutic use , Itraconazole/therapeutic use , Lung Diseases, Fungal/complications , Lung Diseases, Fungal/drug therapy , Middle Aged , Mitral Valve Insufficiency/diagnostic imaging , Mitral Valve Insufficiency/microbiology , Mitral Valve Insufficiency/surgery , Opportunistic Infections/complications , Opportunistic Infections/drug therapy , Opportunistic Infections/surgery , Papillary Muscles , Postoperative Complications/microbiology , Prednisolone/adverse effects , Prednisolone/therapeutic use , Pseudomonas Infections/complications , Recurrence , Rupture, Spontaneous , Shock, Septic/etiology , Shock, Septic/microbiology , Sputum/microbiology , Ultrasonography , Urinary Tract Infections/complications , Urinary Tract Infections/drug therapy , Urinary Tract Infections/microbiology
2.
N Engl J Med
; 350(11): 1152-5; author reply 1152-5, 2004 Mar 11.
Article
in English
| MEDLINE
| ID: mdl-15017684
3.
Intensive Care Med
; 28(5): 663-4, 2002 May.
Article
in English
| MEDLINE
| ID: mdl-12029421
