Subject(s)
Antifungal Agents/pharmacokinetics , Dermatologic Agents/pharmacokinetics , Isotretinoin/pharmacokinetics , Itraconazole/pharmacokinetics , Tinea/drug therapy , Tinea/metabolism , Administration, Oral , Antifungal Agents/administration & dosage , Dermatologic Agents/administration & dosage , Drug Interactions/physiology , Drug Therapy, Combination , Humans , Isotretinoin/administration & dosage , Itraconazole/administration & dosage , Treatment OutcomeABSTRACT
BACKGROUND: Erythema nodosum leprosum (ENL) classically presents as tender evanescent skin nodules involving extremities, trunk, and face but may appear at any site. Mucosal involvement in ENL is uncommon, and its occurrence over glans is extremely rare. METHOD: We describe two interesting cases of ENL involving the glans penis and prepuce with different presentations. RESULT: The first case had lepromatous leprosy with ENL with involvement of the glans penis in the form of a painful ulcer with necrotic slough. The second case had borderline lepromatous leprosy with ENL with involvement of glans in the form of a single painful nodule. Histopathology showed features of ENL, and Ziehl-Neelsen staining showed numerous acid fast bacilli. CONCLUSION: We should be aware of genital involvement of ENL, which is a rare presentation and needs to be differentiated from other conditions requiring a different management approach.
Subject(s)
Erythema Nodosum/pathology , Leprosy, Lepromatous/pathology , Mycobacterium leprae/isolation & purification , Penile Diseases/microbiology , Penis/pathology , Adult , Drug Therapy, Combination , Erythema Nodosum/diagnosis , Erythema Nodosum/drug therapy , Follow-Up Studies , Humans , Immunohistochemistry , Leprosy, Lepromatous/diagnosis , Leprosy, Lepromatous/drug therapy , Male , Middle Aged , Penile Diseases/drug therapy , Penile Diseases/pathology , Risk Assessment , Sampling Studies , Severity of Illness Index , Treatment OutcomeABSTRACT
Cysticercosis, especially neurocysticercosis, is a major public health problem in India. We report an unusual case of disseminated cysticercosis with extensive infiltration of the skin, central nervous system, skeletal muscles, eye, lung, and heart. A patient with extensive cutaneous cysticercosis must be thoroughly investigated for widespread internal organ involvement.
