ABSTRACT
The paper gives the results of 4-year monitoring of the total mutagenic activity of snow samples from different Magnitogork areas in a test for induction of dominant lethal mutations (DLM) in the gametes of Drosophila melanogaster. An association was first found between the rate of DLM and the content of some chemical compounds in the ambient air and snow samples; moreover all the substances present in the samples, which had found genotoxic effects, showed a positive correlation with the rate of DLM. Furthermore, direct correlations were first established between the rate of DLM and the air pollution index and morbidity rates in 5-7-year-old children residing in the areas under study. The findings allow the test for induction of dominant lethal mutations (DLM) in the gametes of Drosophila melanogaster to be recommended due to its unique informative and prognostic value for monitoring ambient air pollution and for extensive use in the risk assessment system.
Subject(s)
Air Pollutants/analysis , Environmental Monitoring/methods , Hygiene/standards , Mutagens/analysis , Snow/chemistry , Air Pollutants/toxicity , Animals , Child , Child, Preschool , Cities , Cytogenetic Analysis , Drosophila melanogaster/drug effects , Drosophila melanogaster/genetics , Germ Cells/cytology , Germ Cells/drug effects , Humans , Male , Morbidity/trends , Mutagenicity Tests , Mutagens/toxicity , Mutation , Risk Assessment , RussiaABSTRACT
The paper gives the data of experimental studies of oral trivalent antimony used at 1 and 20 maximum permissible concentrations (MPC) on the rat hormonal status. The findings are indicative of the specific features of changes in the hormonal status of experimental animals depending on the dose of trivalent antimony. The concentration of trivalent antimony at the level of 20 MPC is shown to act as a role of a reprotoxic agent that causes a change in the serum content of hormones, such as follicle-stimulating and luteinizing ones.
