Multifunctional Self-Healing Carbon Dot-Gelatin Bioadhesive: Improved Tissue Adhesion with Simultaneous Drug Delivery, Optical Tracking, and Photoactivated Sterilization.

Bioadhesives with all-inclusive properties for simultaneous strong and robust adhesion, cohesion, tracking, drug delivery, self-sterilization, and nontoxicity are still farfetched. Herein, a carbon dot (CD) is made to infuse each of the above-desired aspects with gelatin, an inexpensive edible protein. The CD derived through controlled hydrothermal pyrolysis of dopamine and terephthaldehyde retained -NH2, -OH, -COOH, and, most importantly, -CHO functionality on the CD surface for efficient skin adhesion and cross-linking. Facile fabrication of CD-gelatin bioadhesive through covalent conjugation of -CHO of the CD with -NH2 of gelatin through Schiff base formation was accomplished. This imparts remarkable self-healing attributes as well as excellent adhesion and cohesion evident from physicomechanical analysis in a porcine skin model. Improved porosity of the bioadhesive allows loading hemin as a model drug whose disembarkment is tracked with intrinsic CD photoluminescence. In a significant achievement, antibiotic-free self-sterilization of bioadhesive is demonstrated through visible light (white LED, 23 W)-irradiated photosensitization of the CD to produce reactive oxygen species for annihilation of both Gram-positive and Gram-negative bacteria with exceptional efficacy (99.9%). Thus, a comprehensive CD-gelatin bioadhesive for superficial and localized wound management is reported as a promising step for the transformation of the bioadhesive domain through controlled nanotization for futuristic clinical translations.

Unique Compatibilized Thermoplastic Elastomer with High Strength and Remarkable Ductility: Effect of Multiple Point Interactions within a Rubber-Plastic Blend.

In the case of thermoplastic elastomers (TPEs) based on nonpolar polypropylene (PP) and polar rubbers, a small quantity of a third component known as the compatibilizer is added to maximize the compatibility between the incompatible blend components. Generally, one part of the compatibilizer reacts with the nonpolar PP phase and the other part of the compatibilizer reacts with the polar rubber phase, which in turn produces TPEs with useful properties. Till today, there have been no reports in the literature that examine the effect of a compatibilizer that can have multifaceted interactions with the incompatible blend components for the development of TPEs with unique properties. Accordingly, here, an ethylene-acrylic ester-maleic anhydride terpolymer (E-AE-MA-TP) has been used as the compatibilizer for the preparation of TPEs based on nonpolar isotactic polypropylene (i-PP) and polar epichlorohydrin rubber (ECR). The E-AE-MA-TP compatibilizer contains ethylene groups, acrylic groups, and anhydride/acid groups along its backbone, which act as the sites for establishing multifaceted interactions with both i-PP and ECR. The compatibilization efficiency of the E-AE-MA-TP compatibilizer has been analyzed by contact angle measurements, Fourier transform infrared (FTIR) spectroscopy, tensile stress-strain studies, mixing torque profiles, rheological studies, differential scanning calorimetry (DSC), field emission scanning electron microscopy (FESEM), and atomic force microscopy (AFM) images. The particle size of the dispersed ECR domains in the i-PP matrix of the i-PP/ECR blend prominently decreases (∼90% reduction) by incorporation of a very low dosage (5 wt %) of the E-AE-MA-TP compatibilizer. The i-PP/ECR (40 wt %/60 wt %) blend containing 5 wt % compatibilizer displays outstanding mechanical properties (especially strain at break value (∼370%)), which are superior to the mechanical properties of several compatibilized TPEs (based on PP and polar rubbers) reported in the literature. The unique properties of TPEs based on i-PP and ECR in the presence of the E-AE-MA-TP compatibilizer is attributed to the efficacy of the E-AE-MA-TP compatibilizer to establish multifaceted interactions with both i-PP and ECR.