[Production of tumor necrosis factor-alpha and interleukin-1 beta in patients with pulmonary tuberculosis in relation to the course of a process and immunological features]. / Produktsiia faktora nekroza opukholei alpha i interleikina-1beta u bol'nykh tuberkulezom legkikh v zavisimosti ot techeniia protsessa i osobennostei immuniteta.

The production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) by peripheral mononuclears induced by prodigiosane, tuberculin, phytohemagglutinin and unduced and the serum levels of the above cytokines were studied. There was an relationship between the production of TNF-alpha in the patients' peripheral blood and the type and pattern of a tuberculosis process. The similar tendencies were found in the production of IL-1 beta. It was found that the production of IL-1 beta was higher in patients with a more predominant humoral immune response and that of TNF-alpha was greater in those with a more cellular response. There were the most marked relationships of cytokine synthesis to the degree of clinical parameters in prodigiosan cell induction of cells and to immunological parameters in tuberculin-induced cell stimulation.

[Time factors in the acoustic reflex of intra-aural muscles and brain stem acoustic evoked potentials in workers with occupational hearing loss and normal and delayed speech discrimination]. / Vremennye pokazateli akusticheskogo refleksa vnutriushnykh myshts i stvolomozgonykh slukhovykh vyzvannykh potentsialov u rabochikh, stradaiushchikh professionalnoi tugoukhostíu, s normalnym i zamedlennym narastaniem razborchivosti slovesnogo testa.

Time characteristics of brain stem acoustic evoked potentials and acoustic reflex of the intra-aural muscles were measured in workers with occupational hypoacusis having normal and delayed capacity for speech discrimination. The findings provided evidence for inhibition of speech information analysis at the level of the brain stem and dissociation of interaction between the brain stem nuclei.

[State of auditory function based on data of audiometry and dynamic impedance-metry in persons exposed to radiation during liquidation of the Chernobyl AES accident]. / Sostoianie slukhovoi funktsii po dannym audiometrii i dinamicheskoi impedansometrii u lits, podvergshikhsia radiatsionnomu oblucheniiu pri likvidatsii avariina ChAES.

A total of 251 men at the age of 23 to 50 have been examined with the use of audiometry and dynamic impedance metry who had obtained various doses of radiation connected with the work at the Chernobyl Power Plant. It was established that in 57.8% of the cases the audition was within the physiological norm and in 42.2% various forms of audition derangements were diagnosed.

[Amplitude and time characteristics of latent auditory evoked potentials in occupational hearing disorders with and without the recruitment phenomenon]. / Amplitudnye i vremennye kharakteristiki dlinnolatentnykh slukhovykh potentsialov pri professional'nykh narusheniiakh slukha s fenomenom uskorennogo narastaniia gromkosti i bez nego.

Cortical evoked potentials (CEP) of workers exposed to industrial noise were recorded by an Amplaid MK-6 unit (Italy). They suffered from neurosensory hypoacusis with or without the recruitment phenomenon. The results were compared with those derived from patients with neurosensory hypoacusis of vascular origin, aggravated by the recruitment phenomenon, and in the cortical structures of the hearing organ in the case of neurosensory hypoacusis of both vascular and noise origin. Increase of the N2 with observations made on normal controls who were not exposed to industrial noise. CEP were found to give reliable information about changes peak latency may be used for differential diagnosis of neurosensory hypoacusis of vascular or noise origin. Decrease of the P2--N2 amplitude in response to 1 kHz stimulation may also help discriminate neurosensory hypoacusis of vascular or noise origin.