[Study of giant depolarizing activity in the neonatal hippocampal neurones]. / Issledovanie mekhanizma vozniknoveniya gigantskikh depoliariziruiushchikh potentsialov v neironakh gippokampa novorozhdennykh krys.

Spontaneous oscillatory activity is a general feature of developing neural networks. Early in postnatal development, spontaneous network-driven events, termed giant depolarizing potentials (GDPs), occur synchronously over the entire hippocampus. By performing simulation of hippocampal network with using physiology parameters of the neurons and its network from the present experiments and literature dates, we investigated the participation of the different components of network in the generation of GDPs. Comparing the results of the model and in vitro experiments we conclude that are necessary for the GDP generation involvement the activation of GABAergic, glutamatergic inputs and perhaps gap junction.

[Effects of induction propofol mono-narcosis on the central and cerebral hemodynamics]. / Vliianie vvodnogo mononarkoza propofolom na tsentral'nuiu i tserebral'nuiu gemodinamiku.

Changes in the central hemodynamics were followed up by echocardiography and the linear velocity of the bloodflow by transcranial dopplerography in 15 patients with ASA classes I-II during induction bolus anesthesia with propofol in a dose 2.7 mg/kg without opioids. The diastolic and mean arterial pressure decreased by 12.3 and 15.4 %, respectively, the rate of cardiac contractions by 7.8%, cardiac index by 13.4%, and the resistive index on the radial and middle cerebral arteries by 13.4 and 10.2%, respectively, after administration of the above dose of propofol. The reaction to intubation of the trachea was the minimal, consisting in an increase of the mean and systolic arterial pressure by 22.2 and 22.7%, respectively, and of diastolic by 16.1%. The rest parameters were as initially. The linear velocity of the bloodflow in the middle cerebral artery did not reliably change. Hence, the central hemodynamic parameters are stable on condition that the deficit in the central bloodflow during induction anesthesia with propofol in a dose of 2.7 mg/kg is compensated for, adequate protection from intubation stress is provided, and autoregulation of the cerebral bloodflow is preserved.

[Features of the clinical picture and diagnosis of nonspecific aorto-arteritis with lesions of the arch of the aorta]. / Osobennosti kliniki i diagnostiki nespetsificheskogo aortoarterita s porazheniem vetvei dugi aorty.

A total of 68 patients with non-specific aortoarteritis (NAA) and the involvement of the aortic arch and its branches were observed. The onset of disease in a young age, a high frequency of cerebro-ischemic disorders and involvement of the other vascular regions, late diagnosis were typical signs. Knowledge of NAA clinical peculiarities, thorough examination of patients using physical and instrumental methods turned out decisive in diagnosis.