ABSTRACT
Surgery was performed in 161 patients with primary hyperparathyroidism (PHPT). Eight of 161 patients underwent repeated surgeries. In 6 patients persistent PHPT was associated with hyperplasia of parathyroid glands (PTG), in 1 -- with adenoma of PTG missed during the first surgery. In 4 of them hyperplastic PTG are located in anterior mediastinum, in 1 -- in posterior. In 2 patients with verified hyperplasia of PTG repeated surgeries were limited in the region of the neck. During repeated surgery in one patient recurrence of PTG cancer was diagnosed. Specific group consisted of 8 patients with non-severe disturbances of renal function which remained in early and long-term period after surgery. Levels of parathyroid hormone and ionized calcium were normal or insignificantly elevated. Dynamic observation was recommended for all patients of this group.
Subject(s)
Hyperparathyroidism/surgery , Parathyroid Glands/pathology , Adenoma/complications , Adenoma/pathology , Adenoma/surgery , Adolescent , Adult , Aged , Calcium/blood , Humans , Hyperparathyroidism/blood , Hyperparathyroidism/etiology , Hyperplasia/complications , Middle Aged , Parathyroid Glands/surgery , Parathyroid Hormone/blood , Parathyroid Neoplasms/complications , Parathyroid Neoplasms/pathology , Parathyroid Neoplasms/surgery , ReoperationSubject(s)
Calcinosis/etiology , Diagnostic Errors , Hyperparathyroidism/complications , Hyperparathyroidism/diagnosis , Adult , Calcinosis/pathology , Cardiomyopathies/etiology , Colonic Diseases/etiology , Female , Humans , Hyperparathyroidism/pathology , Liver Diseases/etiology , Lung Diseases/etiology , Nephrocalcinosis/etiologyABSTRACT
A case of primary hyperparathyroidism (PHPT) in a patient 47 years of age diagnosed only at autopsy is reported. PHPT deposits of calcium into the muscles and heart vessels provoked irreversible cardiovascular disorders which caused death. Renal lesions were intravitally diagnosed as isolated urolithiasis but not as manifestations of PHPT. High blood levels of ionised calcium in this patient were thought a laboratory mistake though the above clinical symptoms should have excluded such opinion.
Subject(s)
Adenoma/diagnosis , Calcium Compounds/metabolism , Hyperparathyroidism/diagnosis , Hyperparathyroidism/etiology , Parathyroid Neoplasms/diagnosis , Adenoma/complications , Adenoma/metabolism , Autopsy , Diagnosis, Differential , Humans , Hypercalcemia/complications , Hypercalcemia/etiology , Hyperparathyroidism/metabolism , Kidney Calculi/etiology , Male , Middle Aged , Myocardial Infarction/etiology , Parathyroid Neoplasms/complications , Parathyroid Neoplasms/metabolismABSTRACT
An analysis of 149 cases of primary hyperparathyroidism has shown that 83 (55.7%) patients had different kinds of pathology of the thyroid gland. The authors recommend to perform thorough revision and biopsy of the thyroid tissue in all the patients operated upon for primary hyperparathyroidism.
Subject(s)
Hyperparathyroidism/complications , Thyroid Diseases/complications , Thyroid Gland/pathology , Adolescent , Adult , Aged , Biopsy , Female , Humans , Hyperparathyroidism/pathology , Hyperparathyroidism/surgery , Male , Middle Aged , Thyroid Diseases/pathology , Thyroid Gland/surgeryABSTRACT
Possible decreasing of the Corynebacterium diphtheriae adhesive activity by natural biopolymers was studied. It was shown that the strains of C.diphtheriae circulating on the Primorye Territory had middle, low or minimal adhesive activity. Natural biopolymers were found to decrease the adhesive properties of C.diphtheriae. The results of the study are promising for further investigation of natural biopolymers as agents preventing C.diphtheriae colonization on the stomatopharynx mucosa.
