[The role of peptides in the cholinergic and adrenergic mechanisms of the regulation of gastric secretion]. / Rol' peptydiv u kholinerhichnykh i adrenerhichnykh mekhanizmakh rehuliatsiï shlunkovoi sekretsiï.

With using pharmacological analysis of stimulation or blockage of enterocytes cholin- or adrenergic receptors chronic experiments on dogs with gastric fistulas were carried out to study the influence of peptides on gastric acid secretion stimulated by pentagastrin or histamine. The different peptides (met- and leu-enkephalins, substance P, angiotensins I and II, oxytocin, pentagastrin) and internal secretion hormones (insulin, glucagon) were infused parenterally under the stimulated gastric secretion. It is proposed the model of the peripheral link of neurohumoral regulation of gastric acid secretion in the stomach.

[A pharmacological analysis of the effect of angiotensin on stimulated gastric secretion]. / Farmakolohichnyi analiz vplyvu anhiotenzynu na stymul'ovanu shlunkovu sekretsiiu.

Chronic experiments on dogs with gastric fistulas were carried out to study the influence of angiotensin 1 and angiotensin 2 on pentagastrin- and histamine-induced gastric acid secretion. It was established that both angiotensins inhibited gastric acid secretion stimulated by pentagastrin but not by histamine. Comparative analysis of the effects of stimulation and inhibition of cholino- and adrenoreceptors on this inhibitory action of angiotensins suggested the mediation of angiotensin influence through the modulation of cholinergic reactions of parietal cells in the stomach.

[The effect of pentagastrin and substance P on the gastric parietal glandulocytes]. / Vliianie pentagastrina i substantsii P na parietal'nye glandulotsity zheludka.

Investigations on dogs show that substance P suppresses pentagastrin gastric acid secretion. This effect is abolished by acetylcholinesterase block by calimin. The results indicate that pentagastrin and substance P participate in cholinergic regulation of gastric acid secretion.