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DKK1 is a strong candidate for mesiodens and taurodontism.
Kantaputra, Piranit; Jatooratthawichot, Peeranat; Kottege, Naomi; Anthonappa, Robert P; Kaewgahya, Massupa; Tongsima, Sissades; Ngamphiw, Chumpol; Ketudat Cairns, James R; Predes, Danilo; He, Xi.
Clin Genet ; 103(6): 714-716, 2023 06.
Article in English | MEDLINE | ID: mdl-36601665

ABSTRACT

A mutation in DKK1 gene leads to inhibitory DKK1 function, over-activation of WNT/ß-catenin signaling, disruptive development of dental epithelium, and subsequent mesiodens formation.


Subject(s)
Tooth Abnormalities , Humans , Wnt Signaling Pathway , beta Catenin , Intercellular Signaling Peptides and Proteins
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