Subject(s)
Intubation, Intratracheal/adverse effects , Intubation, Intratracheal/instrumentation , Respiratory Insufficiency/therapy , Tracheoesophageal Fistula/etiology , Tracheostomy/adverse effects , Tracheostomy/instrumentation , Female , Humans , Middle Aged , Necrosis/etiology , Pressure/adverse effects , Tracheoesophageal Fistula/pathologyABSTRACT
Tamsulosin hydrochloride is used to treat the symptoms of an enlarged prostate, a condition technically known as benign prostatic hyperplasia or BPH. The analyte was resolved by using mobile phase (potassium dihydrogen orthophosphate and acetonitrile) at the flow rate of 1.2 Ml/Min. on isocratic HPLC system consisting of Jasco Make UV visible detector of model UV 1575 and Jasco make HPLC pump of model PU 1580. An ODS C-8 RP column (4.6 mm ID, 250 mm L, particle size 5 micron, at wavelength of 280 Nm. The linearity range was found to be 0.4 Ml/Ml for tamsulosin and 0.12 mg/ml to 2.0 mg/ml for its impurity. The proposed method is simple, accurate, rapid and selective. Percent relative standard deviation was found to be very low, below 2.0%, which indicates that method is highly precise and specific. Short analysis time (<10 min.) coupled with simplicity and ease of operation warrants use of the given method for analysis of tamsulosin hydrochloride along with its impurity as stated above in bulk. Therefore, method can be useful in routine quality control analysis in bulk drugs.
Subject(s)
Antineoplastic Agents/analysis , Chromatography, High Pressure Liquid , Drug Contamination/prevention & control , Sulfonamides/analysis , Technology, Pharmaceutical/methods , Quality Control , Reproducibility of Results , TamsulosinABSTRACT
A simple, Precise, Rapid reproducible and selective reverse phase HPLC method has been developed for the estimation of Sibutramine Hydrochloride monohydrate and its Impurity in Bulk as well as Formulation. The analyte was resolved by using Mobile phase (Sodium Dihydrogen phosphate and Acetonitrile) at the flow rate of 1.0 Ml/Min. on Isocratic HPLC system consisting of Jasco Make UV visible Detector of model UV 1575 & Jasco make HPLC pump of model PU 1580. An ODS C- 8 RP Column (4.6mm ID, 250mm L, particle size 5 Micron, at wavelength of 230 nm.
Subject(s)
Chromatography, High Pressure Liquid/methods , Cyclobutanes/chemistry , Antidepressive Agents/chemistry , Antidepressive Agents/isolation & purification , Chemistry, Pharmaceutical/methods , Cyclobutanes/isolation & purification , Pharmaceutical Preparations/analysis , Quality Control , Reproducibility of Results , Sensitivity and SpecificityABSTRACT
Kimura's disease is a chronic inflammatory disorder involving the skin, subcutaneous tissues and lymph nodes, predominantly in the head and neck region. Though surgery, intralesional or systemic steroids or radiation therapy have been the mainstay of treatment recurrence is a common problem. On the basis of occasional case report of Kimura's disease responding to cyclosporine, we attempted oral cyclosporine in our patient with dramatic improvement.
Subject(s)
Angiolymphoid Hyperplasia with Eosinophilia/drug therapy , Cyclosporine/therapeutic use , Adult , Angiolymphoid Hyperplasia with Eosinophilia/physiopathology , Humans , Male , RecurrenceABSTRACT
A 36-year-old male patient, a known case of retroviral disease, presented with clinical features suggestive of pneumonia and was found to have bilateral lower zone lung consolidation which on resolution showed a cystic change on the chest radiograph. A subsequent CT scan revealed the true nature of these cysts to be ruptured pulmonary hydatid cysts showing a 'water lily sign'. The rare association of pulmonary hydatid cyst and HIV from India is described.
Subject(s)
Echinococcosis, Pulmonary/complications , Echinococcosis, Pulmonary/diagnosis , HIV Infections/complications , HIV-1 , Adult , Echinococcosis, Pulmonary/therapy , Humans , India , MaleABSTRACT
Plus minus lid syndrome is an ocular syndrome characterized by unilateral ptosis and contralateral lid retraction. Also when the ipsilateral lid is raised manually, the contralateral retracted lid does not revert. This patient presented with features of plus minus lid syndrome with ataxia due to a vascular mesencephalic lesion.
